MGI phenotypes (allele matching)
B6;129P2-Adgrl2tm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02294 |
| International strain name | B6;129P2-Adgrl2tm1Dgen/H |
| Alternative name | DELTAGEN_T821 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Adgrl2tm1Dgen |
| Gene/Transgene symbol | Adgrl2 |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Embryonic Lethality : Homozygous mutant embryos die at ~ E15.5. Behavior: Heterozygous mutant mice exhibited significantly decreased total distance traveled during open field testing when compared with age- and gender-matched wild-type control mice. There were no other significant differences detected in the heterozygous mutant animals when compared with age- and gender-matched wild-type control mice. Weaned progeny from the heterozygous matings were genotyped. No homozygous mutant mice were identified by PCR, whereas wild-type and heterozygous mutant mice were present. The genotypic ratio suggested an embryonic lethal phenotype. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.;Hamann Jörg, Aust Gabriela, Araç Demet, Engel Felix B, Formstone Caroline, Fredriksson Robert, Hall Randy A, Harty Breanne L, Kirchhoff Christiane, Knapp Barbara, Krishnan Arunkumar, Liebscher Ines, Lin Hsi-Hsien, Martinelli David C, Monk Kelly R, Peeters Miriam C, Piao Xianhua, Prömel Simone, Schöneberg Torsten, Schwartz Thue W, Singer Kathleen, Stacey Martin, Ushkaryov Yuri A, Vallon Mario, Wolfrum Uwe, Wright Mathew W, Xu Lei, Langenhan Tobias, Schiöth Helgi B, ;2015;Pharmacological reviews;67;338-67; 25713288
- Latrophilin2 is involved in neural crest cell migration and placode patterning in Xenopus laevis.;Yokote Natsumi, Suzuki-Kosaka Marianna Y, Michiue Tatsuo, Hara Takahiko, Tanegashima Kosuke, ;2019;The International journal of developmental biology;63;29-35; 30919913