B6;129P2-Adamts1^tm1Dgen/H

Status	Available to order
EMMA ID	EM:02291
Citation information	RRID:IMSR_EM:02291 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;129P2-Adamts1^tm1Dgen/H
Alternative name	DELTAGEN_T1228
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Adamts1^tm1Dgen
Gene/Transgene symbol	Adamts1

Information from provider

Provider	Deltagen Inc.
Provider affiliation	Deltagen Inc.
Phenotypic information	Necropsy: Kidney enlarged and fluid-filled, 49 day homozygous mutant females and males. Weight and/or organ weight/body weight ratio increased, 49 day homozygous mutant females and males. Discolored, 49 day homozygous mutant male. Histopathology: Kidney Pelvis dilated, bilateral, 49 day homozygous females and males; unilateral, 49 day homozygous female. Cortex atrophic, 49 day homozygous females and males.
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)

abnormal tail morphology / IMPC
abnormal spleen morphology / IMPC
abnormal placenta vasculature / IMPC
no spontaneous movement / IMPC
abnormal placenta morphology / IMPC
abnormal kidney morphology / IMPC
abnormal blood vessel morphology / IMPC
eye hemorrhage / IMPC
abnormal body wall morphology / IMPC
small kidney / IMPC
preweaning lethality, incomplete penetrance / IMPC
enlarged spleen / IMPC
abnormal heart morphology / IMPC
small heart / IMPC
abnormal eye morphology / IMPC

MGI phenotypes (allele matching)

hydronephrosis / MGI
abnormal kidney morphology / MGI
enlarged kidney / MGI
increased kidney weight / MGI
kidney cortex atrophy / MGI

MGI phenotypes (gene matching)

hydronephrosis / MGI
abnormal ureter morphology / MGI
dilated uterus / MGI
decreased body weight / MGI
impaired embryo implantation / MGI
polyuria / MGI
reduced female fertility / MGI
decreased litter size / MGI
abnormal kidney morphology / MGI
decreased mature ovarian follicle number / MGI
enlarged kidney / MGI
decreased ovulation rate / MGI
ureter obstruction / MGI
increased kidney weight / MGI
homeostasis/metabolism phenotype / MGI
decreased urine potassium level / MGI
decreased urine sodium level / MGI
abnormal adrenal medulla morphology / MGI
uterus cysts / MGI
decreased total body fat amount / MGI
postnatal lethality, incomplete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI
absent kidney papilla / MGI
dilated kidney calyx / MGI
abnormal kidney corticomedullary boundary morphology / MGI
kidney medulla atrophy / MGI
kidney cortex atrophy / MGI
decreased urine chloride ion level / MGI
abnormal ureteropelvic junction morphology / MGI
ureteropelvic junction obstruction / MGI
kidney papillary hypoplasia / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

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