C57BL/6-Tg(KRT5-Trp63_ideltaN)1Gml/Cnrm

Status	Available to order
EMMA ID	EM:02284
Citation information	RRID:IMSR_EM:02284 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6-Tg(KRT5-Trp63_ideltaN)1Gml/Cnrm
Alternative name	Tg:DeltaNp63alpha-HA
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(KRT5-Trp63_ideltaN)1Gml
Gene/Transgene symbol	Tg(KRT5-Trp63_ideltaN)1Gml

Information from provider

Provider	Gerry Melino
Provider affiliation	University of Tor Vergata
Genetic information	A recombination vector containing the K5 promoter (from Dr Manfred Blessing, Joannes Gutemberg University, Mainz, Germany) and the PolyA+ signal was used. Mouse DeltaNp63alpha cDNA was tagged at the N-terminus (hemagglutinin-antigen, HA) and cloned into the vector using ClaI restriction sites located between the promoter and the polyA+ cassette. The fragment containing the expression cassette (K5promoter/DeltaNp63alpha/ polyA+ signal) was released using KpnI.
Phenotypic information	None.
Breeding history	Heterozygous mice are bred with wild-type mice and transgenic mice are selected upon genotype screening.
References	Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.;Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli L G, Catani M V, Ramadan S, Knight R A, Melino G, ;2006;Cell death and differentiation;13;1037-47; 16601749 DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.;Candi Eleonora, Rufini Alessandro, Terrinoni Alessandro, Giamboi-Miraglia Alessandro, Lena Anna Maria, Mantovani Roberto, Knight Richard, Melino Gerry, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;11999-2004; 17626181

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.;Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli L G, Catani M V, Ramadan S, Knight R A, Melino G, ;2006;Cell death and differentiation;13;1037-47; 16601749
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.;Candi Eleonora, Rufini Alessandro, Terrinoni Alessandro, Giamboi-Miraglia Alessandro, Lena Anna Maria, Mantovani Roberto, Knight Richard, Melino Gerry, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;11999-2004; 17626181

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

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