B6.129-Cnr2tm1Zim/Ieg

Status

Available to order

EMMA IDEM:02275
Citation informationRRID:IMSR_EM:02275 

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International strain nameB6.129-Cnr2tm1Zim/Ieg
Alternative nameCnr2 tm2zim
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCnr2tm1Zim
Gene/Transgene symbolCnr2

Information from provider

ProviderAndreas Zimmer
Provider affiliationInstitute of Molecular Psychiatry
Genetic information341 nucleotides were deleted from the 3' end of the single exon and replaced with a neomycin selection cassette. The deleted region encoded a portion of the intracellular loop 3, transmembrane domains 6 and 7, and the C-terminus. PMID: 10822068.
Phenotypic informationOsteoporosis, liver fibrosis susceptibility, atherosclerosis susceptibility.
Breeding historyBackcrossed for at least 10 generations to C57BL/6J mice.
References
  • Attenuation of allergic contact dermatitis through the endocannabinoid system.;Karsak Meliha, Gaffal Evelyn, Date Rahul, Wang-Eckhardt Lihua, Rehnelt Jennifer, Petrosino Stefania, Starowicz Katarzyna, Steuder Regina, Schlicker Eberhard, Cravatt Benjamin, Mechoulam Raphael, Buettner Reinhard, Werner Sabine, Di Marzo Vincenzo, Tüting Thomas, Zimmer Andreas, ;2007;Science (New York, N.Y.);316;1494-7; 17556587
  • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.;Járai Z, Wagner J A, Varga K, Lake K D, Compton D R, Martin B R, Zimmer A M, Bonner T I, Buckley N E, Mezey E, Razdan R K, Zimmer A, Kunos G, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;14136-41; 10570211
  • Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses.;Ohno-Shosaku Takako, Tsubokawa Hiroshi, Mizushima Ichiro, Yoneda Norihide, Zimmer Andreas, Kano Masanobu, ;2002;The Journal of neuroscience : the official journal of the Society for Neuroscience;22;3864-72; 12019305
  • Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation.;Paria B C, Song H, Wang X, Schmid P C, Krebsbach R J, Schmid H H, Bonner T I, Zimmer A, Dey S K, ;2001;The Journal of biological chemistry;276;20523-8; 11279117
  • Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain.;Di Marzo V, Breivogel C S, Tao Q, Bridgen D T, Razdan R K, Zimmer A M, Zimmer A, Martin B R, ;2000;Journal of neurochemistry;75;2434-44; 11080195
  • Peripheral cannabinoid receptor, CB2, regulates bone mass.;Ofek Orr, Karsak Meliha, Leclerc Nathalie, Fogel Meirav, Frenkel Baruch, Wright Karen, Tam Joseph, Attar-Namdar Malka, Kram Vardit, Shohami Esther, Mechoulam Raphael, Zimmer Andreas, Bab Itai, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;696-701; 16407142
  • Cannabinoid receptor type 2 gene is associated with human osteoporosis.;Karsak Meliha, Cohen-Solal Martine, Freudenberg Jan, Ostertag Agnes, Morieux Caroline, Kornak Uwe, Essig Julia, Erxlebe Edda, Bab Itai, Kubisch Christian, de Vernejoul Marie-Christine, Zimmer Andreas, ;2005;Human molecular genetics;14;3389-96; 16204352
  • Physicochemical characterization of protamine-phosphorothioate nanoparticles.;Lochmann D, Vogel V, Weyermann J, Dinauer N, von Briesen H, Kreuter J, Schubert D, Zimmer A, ;2004;Journal of microencapsulation;21;625-41; 15762320
  • [Dentistry, a liberal profession--dream or reality?].;Zimmer A, ;2000;Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia;110;237, 239; 10819675
  • Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.;Buckley N E, McCoy K L, Mezey E, Bonner T, Zimmer A, Felder C C, Glass M, Zimmer A, ;2000;European journal of pharmacology;396;141-9; 10822068

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)
  • enlarged spleen / IMPC
  • enlarged cecum / IMPC
  • abnormal skin morphology / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal kidney morphology / IMPC
  • small kidney / IMPC
  • abnormal cecum morphology / IMPC
  • increased bone mineral content / IMPC
MGI phenotypes (allele matching)
  • abnormal macrophage physiology / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
MGI phenotypes (gene matching)
  • alopecia / MGI
  • abnormal macrophage physiology / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI

Literature references

  • Attenuation of allergic contact dermatitis through the endocannabinoid system.;Karsak Meliha, Gaffal Evelyn, Date Rahul, Wang-Eckhardt Lihua, Rehnelt Jennifer, Petrosino Stefania, Starowicz Katarzyna, Steuder Regina, Schlicker Eberhard, Cravatt Benjamin, Mechoulam Raphael, Buettner Reinhard, Werner Sabine, Di Marzo Vincenzo, Tüting Thomas, Zimmer Andreas, ;2007;Science (New York, N.Y.);316;1494-7; 17556587
  • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.;Járai Z, Wagner J A, Varga K, Lake K D, Compton D R, Martin B R, Zimmer A M, Bonner T I, Buckley N E, Mezey E, Razdan R K, Zimmer A, Kunos G, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;14136-41; 10570211
  • Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses.;Ohno-Shosaku Takako, Tsubokawa Hiroshi, Mizushima Ichiro, Yoneda Norihide, Zimmer Andreas, Kano Masanobu, ;2002;The Journal of neuroscience : the official journal of the Society for Neuroscience;22;3864-72; 12019305
  • Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation.;Paria B C, Song H, Wang X, Schmid P C, Krebsbach R J, Schmid H H, Bonner T I, Zimmer A, Dey S K, ;2001;The Journal of biological chemistry;276;20523-8; 11279117
  • Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain.;Di Marzo V, Breivogel C S, Tao Q, Bridgen D T, Razdan R K, Zimmer A M, Zimmer A, Martin B R, ;2000;Journal of neurochemistry;75;2434-44; 11080195
  • Peripheral cannabinoid receptor, CB2, regulates bone mass.;Ofek Orr, Karsak Meliha, Leclerc Nathalie, Fogel Meirav, Frenkel Baruch, Wright Karen, Tam Joseph, Attar-Namdar Malka, Kram Vardit, Shohami Esther, Mechoulam Raphael, Zimmer Andreas, Bab Itai, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;696-701; 16407142
  • Cannabinoid receptor type 2 gene is associated with human osteoporosis.;Karsak Meliha, Cohen-Solal Martine, Freudenberg Jan, Ostertag Agnes, Morieux Caroline, Kornak Uwe, Essig Julia, Erxlebe Edda, Bab Itai, Kubisch Christian, de Vernejoul Marie-Christine, Zimmer Andreas, ;2005;Human molecular genetics;14;3389-96; 16204352
  • Physicochemical characterization of protamine-phosphorothioate nanoparticles.;Lochmann D, Vogel V, Weyermann J, Dinauer N, von Briesen H, Kreuter J, Schubert D, Zimmer A, ;2004;Journal of microencapsulation;21;625-41; 15762320
  • [Dentistry, a liberal profession--dream or reality?].;Zimmer A, ;2000;Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia;110;237, 239; 10819675
  • Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.;Buckley N E, McCoy K L, Mezey E, Bonner T, Zimmer A, Felder C C, Glass M, Zimmer A, ;2000;European journal of pharmacology;396;141-9; 10822068

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