C57BL/6-Tg(CAG-LEPROTL1)1Blll/Orl

Status	Available to order
EMMA ID	EM:02246
Citation information	RRID:IMSR_EM:02246 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6-Tg(CAG-LEPROTL1)1Blll/Orl
Alternative name	Tg (CMV-ACTB/hLEPROTL1)
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(CAG-LEPROTL1)1Blll
Gene/Transgene symbol	Tg(CAG-LEPROTL1)1Blll

Information from provider

Provider	Bernard BAILLEUL
Provider affiliation	INSERM University Lille2
Genetic information	Randomly expressed; ubiquitous promoter. Protein expression in liver and muscle has been confirmed by Western blot.
Phenotypic information	Growth retardation, decreased liver growth hormone sensitivity.
Breeding history	Direct additive transgenic in inbred C57BL/6. The transgene and the phenotype are stable since at least 5 generations.
References	Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking.;Belgareh-Touzé Naïma, Avaro Sandrine, Rouillé Yves, Hoflack Bernard, Haguenauer-Tsapis Rosine, ;2002;Molecular biology of the cell;13;1694-708; 12006663 Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1).;Huang Y, Ying K, Xie Y, Zhou Z, Wang W, Tang R, Zhao W, Zhao S, Wu H, Gu S, Mao Y, ;2001;Biochimica et biophysica acta;1517;327-31; 11342119 LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.;Touvier Thierry, Conte-Auriol Françoise, Briand Olivier, Cudejko Céline, Paumelle Réjane, Caron Sandrine, Baugé Eric, Rouillé Yves, Salles Jean-Pierre, Staels Bart, Bailleul Bernard, ;2009;The Journal of clinical investigation;119;3830-8; 19907080

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Literature references

Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking.;Belgareh-Touzé Naïma, Avaro Sandrine, Rouillé Yves, Hoflack Bernard, Haguenauer-Tsapis Rosine, ;2002;Molecular biology of the cell;13;1694-708; 12006663
Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1).;Huang Y, Ying K, Xie Y, Zhou Z, Wang W, Tang R, Zhao W, Zhao S, Wu H, Gu S, Mao Y, ;2001;Biochimica et biophysica acta;1517;327-31; 11342119
LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.;Touvier Thierry, Conte-Auriol Françoise, Briand Olivier, Cudejko Céline, Paumelle Réjane, Caron Sandrine, Baugé Eric, Rouillé Yves, Salles Jean-Pierre, Staels Bart, Bailleul Bernard, ;2009;The Journal of clinical investigation;119;3830-8; 19907080

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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