MGI phenotypes (gene matching)
C3Pas.D2-Raz/Ieg
| Status | Available to order |
| EMMA ID | EM:02244 |
| International strain name | C3Pas.D2-Raz/Ieg |
| Alternative name | raz (D470) |
| Strain type | Induced Mutant Strains : Radiation-induced |
| Allele/Transgene symbol | Raz |
| Gene/Transgene symbol | Raz |
Information from provider
| Provider | Jack Favor |
| Provider affiliation | Institute of Human Genetics, Helmholtz Zentrum Muenchen |
| Genetic information | Heterozygous mutants express cataract and polydactyly. Homozygous mutants express extreme polydactyly and are neonatal lethal. Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt. |
| Phenotypic information | Eye: cataract. Limb: polydactyly. |
| Breeding history | Backcrossed to C3H/HeJ more than 20 generations. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud.;Krebs Ottheinz, Schreiner Claire M, Scott William J, Bell Sheila M, Robbins David J, Goetz John A, Alt Heidi, Hawes Norm, Wolf Eckhard, Favor Jack, ;2003;Development (Cambridge, England);130;6037-47; 14597572