B6.Cg-Tyrc-Brd Mir155tm1.1Brd/H

Status

Available to order

EMMA IDEM:02231
International strain nameB6.Cg-Tyrc-Brd Mir155tm1.1Brd/H
Alternative nameBIC
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolMir155tm1.1Brd, Tyrc-Brd
Gene/Transgene symbolMir155, Tyr

Information from provider

ProviderAllan Bradley
Provider affiliationWellcome Trust Sanger Institute
Genetic informationTargeted Deletion of microRNA-155 (aka Bic) by homologous recombination in ES cells using a gene replacement vector. The vector contained a floxed PGK-Neo selection cassette. Mice were obtained and then crossed to CMV-cre recombinase-deleter line to remove the PGK-Neo cassette.
Phenotypic informationImmune-deficient mice. This mutation is on a C57BL/6-Tyrc-Brd/c-Brd background and is albino in appearance. The BIC mice (EMMA ID EM:02231) have been backcrossed at least 5 times to C57BL/6, thus making them suitable for bone marrow transplantation, without rejection, to any C57BL/6 mice, regardless of coat color.
Breeding historyBackcrossed at least 5 times to C57BL/6
References
  • Requirement of bic/microRNA-155 for normal immune function.;Rodriguez Antony, Vigorito Elena, Clare Simon, Warren Madhuri V, Couttet Philippe, Soond Dalya R, van Dongen Stijn, Grocock Russell J, Das Partha P, Miska Eric A, Vetrie David, Okkenhaug Klaus, Enright Anton J, Dougan Gordon, Turner Martin, Bradley Allan, ;2007;Science (New York, N.Y.);316;608-11; 17463290

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased T-helper 2 cell number / MGI
  • decreased IgG1 level / MGI
  • decreased regulatory T cell number / MGI
  • absent skin pigmentation / MGI
  • absent coat pigmentation / MGI
  • decreased eye pigmentation / MGI
MGI phenotypes (gene matching)
  • abnormal immune system morphology / MGI
  • abnormal lung morphology / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • decreased IgM level / MGI
  • intestinal inflammation / MGI
  • lung inflammation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal bronchiole morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal gut-associated lymphoid tissue morphology / MGI
  • abnormal Peyer's patch germinal center morphology / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal B cell physiology / MGI
  • abnormal cytokine secretion / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • abnormal class switch recombination / MGI
  • decreased regulatory T cell number / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased T-helper 2 cell number / MGI
  • decreased germinal center B cell number / MGI
  • abnormal germinal center B cell physiology / MGI
  • decreased spleen germinal center number / MGI
  • decreased spleen germinal center size / MGI
  • decreased IgG1 level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased interleukin-10 secretion / MGI
  • decreased interleukin-4 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • chromosomal instability / MGI
  • decreased T-helper 17 cell number / MGI
  • abnormal T-helper 17 cell differentiation / MGI
  • decreased effector memory T-helper cell number / MGI
  • abnormal cell morphology / MGI
  • diluted coat color / MGI
  • irregular coat pigmentation / MGI
  • belly spot / MGI
  • absent hair follicle melanin granules / MGI
  • shiny fur / MGI
  • mottled coat / MGI
  • abnormal retinal photoreceptor morphology / MGI
  • pigmentation phenotype / MGI
  • absent skin pigmentation / MGI
  • abnormal keratinocyte apoptosis / MGI
  • abnormal eye pigmentation / MGI
  • abnormal retina morphology / MGI
  • retinal degeneration / MGI
  • decreased retinal photoreceptor cell number / MGI
  • abnormal coat appearance / MGI
  • male infertility / MGI
  • abnormal coat/hair pigmentation / MGI
  • prenatal lethality / MGI
  • premature death / MGI
  • abnormal vision / MGI
  • abnormal skin pigmentation / MGI
  • no abnormal phenotype detected / MGI
  • no phenotypic analysis / MGI
  • abnormal cell nucleus morphology / MGI
  • failure of zygotic cell division / MGI
  • single kidney / MGI
  • absent seminal vesicle / MGI
  • abnormal chromosome morphology / MGI
  • chromosome breakage / MGI
  • induced chromosome breakage / MGI
  • increased cellular sensitivity to ionizing radiation / MGI
  • abnormal miscarriage rate / MGI
  • abnormal hair follicle melanogenesis / MGI
  • abnormal melanosome morphology / MGI
  • abnormal iris pigmentation / MGI
  • absent coat pigmentation / MGI
  • decreased eye pigmentation / MGI
  • abnormal aqueous drainage system morphology / MGI
  • abnormal retinal ganglion layer morphology / MGI
  • abnormal eye physiology / MGI
  • abnormal intraocular pressure / MGI
  • variegated coat color / MGI
  • homeostasis/metabolism phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • hypopigmentation / MGI
  • ocular albinism / MGI
  • absent eye pigmentation / MGI
  • decreased survivor rate / MGI
  • transverse fur striping / MGI
  • mortality/aging / MGI
  • abnormal survival / MGI
  • integument phenotype / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality at implantation, complete penetrance / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • decreased ear pigmentation / MGI
  • variegated eye pigmentation pattern / MGI
  • decreased a wave amplitude / MGI
  • decreased b wave amplitude / MGI

Literature references

  • Requirement of bic/microRNA-155 for normal immune function.;Rodriguez Antony, Vigorito Elena, Clare Simon, Warren Madhuri V, Couttet Philippe, Soond Dalya R, van Dongen Stijn, Grocock Russell J, Das Partha P, Miska Eric A, Vetrie David, Okkenhaug Klaus, Enright Anton J, Dougan Gordon, Turner Martin, Bradley Allan, ;2007;Science (New York, N.Y.);316;608-11; 17463290

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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