B6.129S7-Del(16Es2el-Sept5)3Bld/Cnrm
Status | Available to order |
EMMA ID | EM:02225 |
International strain name | B6.129S7-Del(16Es2el-Sept5)3Bld/Cnrm |
Alternative name | 340cdcdel |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Del(16Es2el-Sept5)3Bld |
Gene/Transgene symbol | Del(16Es2el-Sept5)3Bld |
Information from provider
Provider | Antonio BALDINI |
Provider affiliation | institute of biosciences and technologies, Texas A&M health science center |
Genetic information | Es2el (Dgcr14) gene, was inactivated by replacing a 200bp fragment of exon 4, with a construct comprising a PGK promoter-HPRT5' minigene, loxP site, PolII and neo cassette. This line was then retargeted by replacing exons 2-4 of the Cdcrel1 (Sept5) gene with a construct comprising a loxP site and HPRT3' minigene. Generation of the deletion was induced by transient expression of Cre recombinase. |
Phenotypic information | None. |
Breeding history | Backcrossed to C57BL/6 for 7 generations. |
References |
|
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.;Lindsay E A, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jurecic V, Ogunrinu G, Sutherland H F, Scambler P J, Bradley A, Baldini A, ;2001;Nature;410;97-101; 11242049
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).