MGI phenotypes (allele matching)
B6.129S7-Del(16Es2el-Sept5)3Bld/Cnrm
| Status | Available to order |
| EMMA ID | EM:02225 |
| Citation information | RRID:IMSR_EM:02225 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S7-Del(16Es2el-Sept5)3Bld/Cnrm |
| Alternative name | 340cdcdel |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Del(16Es2el-Sept5)3Bld |
| Gene/Transgene symbol | Del(16Es2el-Sept5)3Bld |
Information from provider
| Provider | Antonio BALDINI |
| Provider affiliation | institute of biosciences and technologies, Texas A&M health science center |
| Genetic information | Es2el (Dgcr14) gene, was inactivated by replacing a 200bp fragment of exon 4, with a construct comprising a PGK promoter-HPRT5' minigene, loxP site, PolII and neo cassette. This line was then retargeted by replacing exons 2-4 of the Cdcrel1 (Sept5) gene with a construct comprising a loxP site and HPRT3' minigene. Generation of the deletion was induced by transient expression of Cre recombinase. |
| Phenotypic information | None. |
| Breeding history | Backcrossed to C57BL/6 for 7 generations. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.;Lindsay E A, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jurecic V, Ogunrinu G, Sutherland H F, Scambler P J, Bradley A, Baldini A, ;2001;Nature;410;97-101; 11242049