B6.Cg-B2mtm1Unc Cd4tm1Litt H2-Ab1b-tm1Doi Tg(Cd4-CD4)2362Litt Tg(H2-Aa-HLA-DPA1)1Lone Tg(H2-Ab1-HLA-DPB1)1Lone Tg(HLA-A/H2-D/B2M)1Bpe/Orl

Status

Available to order

EMMA IDEM:02221
Citation informationRRID:IMSR_EM:02221 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.Cg-B2mtm1Unc Cd4tm1Litt H2-Ab1b-tm1Doi Tg(Cd4-CD4)2362Litt Tg(H2-Aa-HLA-DPA1)1Lone Tg(H2-Ab1-HLA-DPB1)1Lone Tg(HLA-A/H2-D/B2M)1Bpe/Orl
Alternative nameHsurivong
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolH2-Ab1b-tm1Doi, B2mtm1Unc, Cd4tm1Litt, Tg(HLA-A/H2-D/B2M)1Bpe, Tg(Cd4-CD4)2362Litt, Tg(H2-Aa-HLA-DPA1)1Lone, Tg(H2-Ab1-HLA-DPB1)1Lone
Gene/Transgene symbolH2-Ab1, B2m, Cd4, Tg(HLA-A/H2-D/B2M)1Bpe, Tg(Cd4-CD4)2362Litt, Tg(H2-Aa-HLA-DPA1)1Lone, Tg(H2-Ab1-HLA-DPB1)1Lone

Information from provider

ProviderYu-Chun LONE
Provider affiliationInstitut Pasteur
Genetic informationPromoter mIAa + cDNA HLA-DPa103, promoter mIAb + cDNA HLA-DPb401.
Breeding historyBackcrossed 6 times to C57BL/6.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J males, homozygous C57BL/6J females
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • small superior vagus ganglion / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • abnormal skin morphology / IMPC
  • hydrometra / IMPC
  • increased circulating phosphate level / IMPC
MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • decreased T cell proliferation / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
MGI phenotypes (gene matching)
  • absent CD8-positive, alpha-beta T cells / MGI
  • decreased IgG level / MGI
  • decreased level of surface class I molecules / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
  • increased IgM level / MGI
  • insulitis / MGI
  • abnormal lateral geniculate nucleus morphology / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • decreased circulating serum albumin level / MGI
  • hemochromatosis / MGI
  • abnormal T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased T-helper 1 cell number / MGI
  • increased gamma-delta T cell number / MGI
  • increased gamma-delta intraepithelial T cell number / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased interleukin-3 secretion / MGI
  • decreased interleukin-4 secretion / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • abnormal spleen morphology / MGI
  • demyelination / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • brain inflammation / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal lymph node T cell domain morphology / MGI
  • abnormal double-positive T cell morphology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal immune system organ morphology / MGI
  • no phenotypic analysis / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • abnormal T cell subpopulation ratio / MGI
  • abnormal bile salt level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • abnormal CD8-positive, alpha beta T cell morphology / MGI
  • decreased T cell number / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased double-positive T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • absent plasma cells / MGI
  • impaired humoral immune response / MGI
  • abnormal immune system morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal immune system cell morphology / MGI
  • hemolytic anemia / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • autoimmune response / MGI
  • reduced fertility / MGI
  • premature death / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal B cell physiology / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal immune system organ morphology / MGI
  • increased urine protein level / MGI
  • abnormal cytokine secretion / MGI
  • abnormal artery development / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • abnormal lymphocyte physiology / MGI
  • insulitis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-single stranded DNA antibody level / MGI
  • increased anti-erythrocyte antigen antibody level / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased susceptibility to experimental autoimmune myasthenia gravis / MGI
  • decreased regulatory T cell number / MGI
  • increased B cell number / MGI
  • decreased susceptibility to parasitic infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal level of surface class II molecules / MGI
  • increased double-negative T cell number / MGI
  • decreased susceptibility to autoimmune disorder / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal response to transplant / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interleukin-12 secretion / MGI
  • abnormal lymph node cell ratio / MGI
  • abnormal neuron proliferation / MGI

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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