IMPC phenotypes (gene matching)
TFH/H
| Status | Available to order |
| EMMA ID | EM:02207 |
| Citation information | RRID:IMSR_EM:02207 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | TFH/H |
| Alternative name | TFH/H |
| Strain type | Spontaneous |
| Allele/Transgene symbol | T, Itpr3tf |
| Gene/Transgene symbol | T, Itpr3 |
Information from provider
| Provider | Mary Lyon |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Genetic information | Homozygous for tufted (Itpr3tf) with forced heterozygosis for T allele. |
| Phenotypic information | Mice heterozygous for TFH/H have short tails. Mice homozygous for this mutation are non-viable. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
- abnormal cerebral cortex morphology / MGI
- increased body weight / MGI
- abnormal social investigation / MGI
- decreased anxiety-related response / MGI
- increased grooming behavior / MGI
- abnormal vocalization / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- increased growth rate / MGI
- impaired social transmission of food preference / MGI
- abnormal locomotor activation / MGI
- decreased hippocampal commissure size / MGI
- decreased anterior commissure size / MGI
- abnormal neocortex morphology / MGI
- abnormal allogrooming behavior / MGI
- excessive vocalization / MGI
- abnormal coat/ hair morphology / MGI
- sparse hair / MGI
- abnormal hair cycle / MGI
- abnormal liquid preference / MGI
- abnormal gustatory system physiology / MGI
- abnormal hair growth / MGI
- increased fluid intake / MGI
- low sweet preference / MGI
MGI phenotypes (gene matching)
- abnormal coat/ hair morphology / MGI
- sparse hair / MGI
- abnormal hair cycle / MGI
- abnormal cerebral cortex morphology / MGI
- increased body weight / MGI
- abnormal social investigation / MGI
- decreased anxiety-related response / MGI
- abnormal liquid preference / MGI
- increased grooming behavior / MGI
- abnormal vocalization / MGI
- abnormal gustatory system physiology / MGI
- abnormal hair growth / MGI
- no abnormal phenotype detected / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- increased growth rate / MGI
- impaired social transmission of food preference / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- decreased hippocampal commissure size / MGI
- decreased anterior commissure size / MGI
- abnormal neocortex morphology / MGI
- abnormal allogrooming behavior / MGI
- increased fluid intake / MGI
- low sweet preference / MGI
- excessive vocalization / MGI
- absent vertebrae / MGI
- rib fusion / MGI
- abnormal heart looping / MGI
- abnormal heart tube morphology / MGI
- distended pericardium / MGI
- increased mast cell number / MGI
- decreased presacral vertebrae number / MGI
- kinked tail / MGI
- short tail / MGI
- abnormal spleen morphology / MGI
- abnormal thymus morphology / MGI
- thymus cortex hypoplasia / MGI
- open neural tube / MGI
- absent notochord / MGI
- abnormal spinal cord morphology / MGI
- seminiferous tubule degeneration / MGI
- abnormal spermatogenesis / MGI
- abnormal epidermal layer morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- decreased caudal vertebrae number / MGI
- abnormal embryo development / MGI
- abnormal axial mesoderm / MGI
- abnormal somite development / MGI
- incomplete somite formation / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- abnormal placenta development / MGI
- abnormal allantois morphology / MGI
- embryonic growth arrest / MGI
- edema / MGI
- hemorrhage / MGI
- reduced fertility / MGI
- reduced male fertility / MGI
- male infertility / MGI
- decreased litter size / MGI
- prenatal lethality / MGI
- perinatal lethality / MGI
- postnatal lethality / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal tail morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal primitive streak formation / MGI
- abnormal thymus cortex morphology / MGI
- increased susceptibility to infection / MGI
- vestigial tail / MGI
- abnormal notochord morphology / MGI
- abnormal tail bud morphology / MGI
- abnormal cervical vertebrae morphology / MGI
- curly tail / MGI
- absent allantois / MGI
- kinked neural tube / MGI
- absent tail / MGI
- abnormal nervous system development / MGI
- abnormal Reichert's membrane morphology / MGI
- embryonic growth retardation / MGI
- disorganized embryonic tissue / MGI
- caudal body truncation / MGI
- transmission ratio distortion / MGI
- failure of heart looping / MGI
- abnormal pelvic girdle bone morphology / MGI
- abnormal cervical atlas morphology / MGI
- vertebral fusion / MGI
- fusion of vertebral arches / MGI
- cervical vertebral fusion / MGI
- thoracic vertebral fusion / MGI
- abnormal odontoid process morphology / MGI
- short ribs / MGI
- notochord degeneration / MGI
- split notochord / MGI
- abnormal dorsal aorta morphology / MGI
- abnormal neural fold formation / MGI
- abnormal trophectoderm morphology / MGI
- abnormal ectoplacental cone morphology / MGI
- abnormal vertebral arch development / MGI
- hemopericardium / MGI
- spina bifida occulta / MGI
- limbs/digits/tail phenotype / MGI
- reproductive system phenotype / MGI
- teratozoospermia / MGI
- abnormal limb bud morphology / MGI
- abnormal tail development / MGI
- absent somites / MGI
- abnormal nucleus pulposus morphology / MGI
- increased megakaryocyte cell number / MGI
- abnormal bone ossification / MGI
- arrest of spermiogenesis / MGI
- decreased spleen white pulp amount / MGI
- embryonic lethality / MGI
- bleb / MGI
- early reproductive senescence / MGI
- absent anus / MGI
- abnormal sperm head morphology / MGI
- abnormal sperm nucleus morphology / MGI
- abnormal manchette morphology / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- decreased embryonic epiblast cell proliferation / MGI
- lethality, complete penetrance / MGI
- abnormal head shape / MGI
- absent tail bud / MGI
- delayed heart development / MGI
- abnormal pericardial cavity morphology / MGI
- decreased ventral ectodermal ridge size / MGI
- abnormal forelimb bud morphology / MGI
- absent forelimb buds / MGI
- absent hindlimb buds / MGI
Literature references
- Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus.;Lyon M F, ;1984;Cell;37;621-8; 6722884