IMPC phenotypes (gene matching)
TFH/H
Information from provider
| Provider | Mary Lyon |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Genetic information | Homozygous for tufted (Itpr3tf) with forced heterozygosis for T allele. |
| Phenotypic information | Mice heterozygous for TFH/H have short tails. Mice homozygous for this mutation are non-viable. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
- abnormal cerebral cortex morphology / MGI
- increased body weight / MGI
- abnormal social investigation / MGI
- decreased anxiety-related response / MGI
- increased grooming behavior / MGI
- abnormal vocalization / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- increased growth rate / MGI
- impaired social transmission of food preference / MGI
- abnormal locomotor activation / MGI
- decreased hippocampal commissure size / MGI
- decreased anterior commissure size / MGI
- abnormal neocortex morphology / MGI
- abnormal allogrooming behavior / MGI
- excessive vocalization / MGI
- abnormal coat/ hair morphology / MGI
- sparse hair / MGI
- abnormal hair cycle / MGI
- abnormal liquid preference / MGI
- abnormal gustatory system physiology / MGI
- abnormal hair growth / MGI
- increased fluid intake / MGI
- low sweet preference / MGI
MGI phenotypes (gene matching)
- abnormal coat/ hair morphology / MGI
- sparse hair / MGI
- abnormal hair cycle / MGI
- abnormal cerebral cortex morphology / MGI
- increased body weight / MGI
- abnormal social investigation / MGI
- decreased anxiety-related response / MGI
- abnormal liquid preference / MGI
- increased grooming behavior / MGI
- abnormal vocalization / MGI
- abnormal gustatory system physiology / MGI
- abnormal hair growth / MGI
- no abnormal phenotype detected / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- increased growth rate / MGI
- impaired social transmission of food preference / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- decreased hippocampal commissure size / MGI
- decreased anterior commissure size / MGI
- abnormal neocortex morphology / MGI
- abnormal allogrooming behavior / MGI
- increased fluid intake / MGI
- low sweet preference / MGI
- excessive vocalization / MGI
- absent vertebrae / MGI
- rib fusion / MGI
- abnormal heart looping / MGI
- abnormal heart tube morphology / MGI
- distended pericardium / MGI
- increased mast cell number / MGI
- decreased presacral vertebrae number / MGI
- kinked tail / MGI
- short tail / MGI
- abnormal spleen morphology / MGI
- abnormal thymus morphology / MGI
- thymus cortex hypoplasia / MGI
- open neural tube / MGI
- absent notochord / MGI
- abnormal spinal cord morphology / MGI
- seminiferous tubule degeneration / MGI
- abnormal spermatogenesis / MGI
- abnormal epidermal layer morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- decreased caudal vertebrae number / MGI
- abnormal embryo development / MGI
- abnormal axial mesoderm / MGI
- abnormal somite development / MGI
- incomplete somite formation / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- abnormal placenta development / MGI
- abnormal allantois morphology / MGI
- embryonic growth arrest / MGI
- edema / MGI
- hemorrhage / MGI
- reduced fertility / MGI
- reduced male fertility / MGI
- male infertility / MGI
- decreased litter size / MGI
- prenatal lethality / MGI
- perinatal lethality / MGI
- postnatal lethality / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal tail morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal primitive streak formation / MGI
- abnormal thymus cortex morphology / MGI
- increased susceptibility to infection / MGI
- vestigial tail / MGI
- abnormal notochord morphology / MGI
- abnormal tail bud morphology / MGI
- abnormal cervical vertebrae morphology / MGI
- curly tail / MGI
- absent allantois / MGI
- kinked neural tube / MGI
- absent tail / MGI
- abnormal nervous system development / MGI
- abnormal Reichert's membrane morphology / MGI
- embryonic growth retardation / MGI
- disorganized embryonic tissue / MGI
- caudal body truncation / MGI
- transmission ratio distortion / MGI
- failure of heart looping / MGI
- abnormal pelvic girdle bone morphology / MGI
- abnormal cervical atlas morphology / MGI
- vertebral fusion / MGI
- fusion of vertebral arches / MGI
- cervical vertebral fusion / MGI
- thoracic vertebral fusion / MGI
- abnormal odontoid process morphology / MGI
- short ribs / MGI
- notochord degeneration / MGI
- split notochord / MGI
- abnormal dorsal aorta morphology / MGI
- abnormal neural fold formation / MGI
- abnormal trophectoderm morphology / MGI
- abnormal ectoplacental cone morphology / MGI
- abnormal vertebral arch development / MGI
- hemopericardium / MGI
- spina bifida occulta / MGI
- limbs/digits/tail phenotype / MGI
- reproductive system phenotype / MGI
- teratozoospermia / MGI
- abnormal limb bud morphology / MGI
- abnormal tail development / MGI
- absent somites / MGI
- abnormal nucleus pulposus morphology / MGI
- increased megakaryocyte cell number / MGI
- abnormal bone ossification / MGI
- arrest of spermiogenesis / MGI
- decreased spleen white pulp amount / MGI
- embryonic lethality / MGI
- bleb / MGI
- early reproductive senescence / MGI
- absent anus / MGI
- abnormal sperm head morphology / MGI
- abnormal sperm nucleus morphology / MGI
- abnormal manchette morphology / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- decreased embryonic epiblast cell proliferation / MGI
- lethality, complete penetrance / MGI
- abnormal head shape / MGI
- absent tail bud / MGI
- delayed heart development / MGI
- abnormal pericardial cavity morphology / MGI
- decreased ventral ectodermal ridge size / MGI
- abnormal forelimb bud morphology / MGI
- absent forelimb buds / MGI
- absent hindlimb buds / MGI
Literature references
- Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus.;Lyon M F, ;1984;Cell;37;621-8; 6722884