| Status | Available to order |
| EMMA ID | EM:00022 |
| International strain name | B6;SJL-Plekha5Tg(AMH-cre)1Flor/Orl |
| Alternative name | AMH-Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Plekha5Tg(AMH-cre)1Flor |
| Gene/Transgene symbol | Plekha5 |
| Provider | Florian GUILLOU |
| Provider affiliation | INRA, INRA |
| Genetic information | A 3.6 Kbp EcoRI/AvrII fragment of the human anti-Mullerian hormone (AMH, or Mullerian inhibitor substance, MIS) gene promoter was inserted upstream of the cre recombinase gene with the metallothionein I polyadenylation signal. The cre gene contains a T to G transversion in the -3 position, relative to the AUG translation start, that increases the translational proficiency of the cre transcript. The insertion site of the original AMH-cre transgene has then been mapped to intron 3 of the Plekha5 gene. |
| Phenotypic information | This line has a scientific interest for conditional gene knock-out in Sertoli cells and granulosa cells. |
| Breeding history | 2 backcrosses to C57BL/6. |
| References |
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| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
