STOCK Tg(ITGAM-PLA2G2A)1Winth/Cnrm
| Status | Available to order |
| EMMA ID | EM:02189 |
| Citation information | RRID:IMSR_EM:02189 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(ITGAM-PLA2G2A)1Winth/Cnrm |
| Alternative name | sPLA2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(ITGAM-PLA2G2A)1Winth |
| Gene/Transgene symbol | Tg(ITGAM-PLA2G2A)1Winth |
Information from provider
| Provider | Menno de Winther |
| Provider affiliation | Institute for Genetics, University of Cologne |
| Genetic information | Transgenic mice were generated using the human sPLA2 gene driven by the ITGAM (CD11b) promoter, leading to myeloid specific overexpression of human group IIa sPLA2. |
| Phenotypic information | Enhanced sPLA2 activity leading to increased atherosclerosis. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.;Ghesquiere Stijn A I, Gijbels Marion J J, Anthonsen Marit, van Gorp Patrick J J, van der Made Ingeborg, Johansen Berit, Hofker Marten H, de Winther Menno P J, ;2005;Journal of lipid research;46;201-10; 15576846