STOCK Tg(MSR1)3Winth/Cnrm
Status | Available to order |
EMMA ID | EM:02188 |
International strain name | STOCK Tg(MSR1)3Winth/Cnrm |
Alternative name | MSR1 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(MSR1)3Winth |
Gene/Transgene symbol | Tg(MSR1)3Winth |
Information from provider
Provider | Menno de Winther |
Provider affiliation | Institute for Genetics, University of Cologne |
Genetic information | Transgenic mice were generated using a 180-kb Yeast Artificial Chromosome (YAC), carrying the complete human macrophage scavenger receptor class A (MSR1 or SR-A) gene including promoter region. This leads to 2-3 fold increased MSR1 activity in macrophages. |
Phenotypic information | Increased scavenger receptor activity |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.;de Winther M P, van Dijk K W, van Vlijmen B J, Gijbels M J, Heus J J, Wijers E R, van den Bos A C, Breuer M, Frants R R, Havekes L M, Hofker M H, ;1999;Atherosclerosis;147;339-47; 10559520
- Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice.;Herijgers N, de Winther M P, Van Eck M, Havekes L M, Hofker M H, Hoogerbrugge P M, Van Berkel T J, ;2000;Journal of lipid research;41;1402-9; 10974047
- Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice.;Van Eck M, De Winther M P, Herijgers N, Havekes L M, Hofker M H, Groot P H, Van Berkel T J, ;2000;Arteriosclerosis, thrombosis, and vascular biology;20;2600-6; 11116059
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