| Status | Available to order |
| EMMA ID | EM:02187 |
| International strain name | B(BR)-Steap3fred/ApbH |
| Alternative name | Redburst |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Steap3fred |
| Gene/Transgene symbol | Steap3 |
| Provider | Chris Goodnow |
| Provider affiliation | The Australian National University |
| Genetic information | This mutation carries a point mutation T to C at nucleotide 862 (Y288H) and was identified during systematically screening of the mouse genome for autoimmune regulators. The mutation results in alteration in red blood cell development. A null mutant has been described which has defects in transferrin mediated iron uptake. |
| Phenotypic information | These mice carry abnormalities in red blood cell size and shape. |
| Breeding history | Original background: C57BL/6Apb. Maintained background: Mixed C57BL/6Apb x B10.BR. Breeding History: From G1 to G5 it was sib x sib mating on B6 background. Then male G5 was outcrossed to female B10.BR. Offspring were then mated sib x sib for two further generations. |
| References | None available |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Orphanet associated rare diseases, based on orthologous gene matching
