MGI phenotypes (allele matching)
C57BL/6Apb-Zap70mur/ApbH
| Status | Available to order |
| EMMA ID | EM:02170 |
| International strain name | C57BL/6Apb-Zap70mur/ApbH |
| Alternative name | Murdoch, C57BL/6Apb-Zap70 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Zap70mur |
| Gene/Transgene symbol | Zap70 |
Information from provider
| Provider | Chris Goodnow |
| Provider affiliation | The Australian National University |
| Genetic information | This stock carries A to T point mutation at nucleotide 1190 (I366F) resulting in protein domain inactivation. This strain was identified during systematically screening of the mouse genome for autoimmune regulators. This mutant strain develops fewer CD4 and CD8 positive cells and autoimmunity. The strain has a similar phenotype to the published gene knock-outs mutants. This strain may assist in the understanding of the molecular requirements for the development of autoimmune disease. |
| Phenotypic information | This strain has the following phenotypic effects: Reduced naive CD4+ and CD8+ T cells which are hyperactivated, reduced CD4+ cells, defect in TCR signal transduction, impaired but not severe response to anti-TCR stimulation, T cell intrinsic defect, elevated serum levels of IgG2b. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined immunodeficiency due to ZAP70 deficiency / Orphanet_911
MGI phenotypes (gene matching)
- osteoporosis / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- mixed cellular infiltration to dermis / MGI
- impaired hematopoiesis / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- increased activated T cell number / MGI
- lung inflammation / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- small lymph nodes / MGI
- abnormal double-positive T cell morphology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T cell physiology / MGI
- increased immunoglobulin level / MGI
- increased IgE level / MGI
- chronic joint inflammation / MGI
- joint swelling / MGI
- arthritis / MGI
- fused joints / MGI
- decreased susceptibility to induced arthritis / MGI
- rheumatoid arthritis / MGI
- increased susceptibility to induced arthritis / MGI
- increased autoantibody level / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal thymocyte activation / MGI
- abnormal T cell subpopulation ratio / MGI
- abnormal class switch recombination / MGI
- abnormal T cell selection / MGI
- abnormal positive T cell selection / MGI
- abnormal regulatory T cell physiology / MGI
- abnormal regulatory T cell number / MGI
- decreased regulatory T cell number / MGI
- abnormal T cell clonal deletion / MGI
- increased B cell number / MGI
- decreased T cell number / MGI
- increased double-positive T cell number / MGI
- decreased T cell proliferation / MGI
- immune system phenotype / MGI
- increased memory T cell number / MGI
- absent T cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal CD8-positive, alpha-beta T cell differentiation / MGI
- increased IgG1 level / MGI
- increased IgG2b level / MGI
- increased interleukin-17 secretion / MGI
- decreased interleukin-2 secretion / MGI
- abnormal splenic cell ratio / MGI
- abnormal thymus cell ratio / MGI
- abnormal lymph node cell ratio / MGI
- increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / MGI
- decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / MGI
- increased central memory CD4-positive, alpha-beta T cell number / MGI
- increased effector memory CD4-positive, alpha-beta T cell number / MGI
- increased central memory CD8 positive, alpha-beta T cell number / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI
- impaired humoral immune response / MGI
- joint dislocation / MGI