B6.Cg-Tg(Ins2-CD80)3B7Flv/Orl
| Status | Available to order |
| EMMA ID | EM:00216 |
| Citation information | RRID:IMSR_EM:00216 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Ins2-CD80)3B7Flv/Orl |
| Alternative name | RIP-B7 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Ins2-CD80)3B7Flv |
| Gene/Transgene symbol | Tg(Ins2-CD80)3B7Flv |
Information from provider
| Provider | Sylvie Guerder |
| Provider affiliation | U136, CIML |
| Phenotypic information | Transgenic expression of human CD80 (B7-1) specifically in the pancreatic beta cells. Increased susceptibility to type 1 diabetes. Increased susceptibility to immune system-mediated diabetes. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.;Guerder S, Eynon E E, Flavell R A, ;1998;Journal of immunology (Baltimore, Md. : 1950);161;2128-40; 9725204
- Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.;Wong S, Guerder S, Visintin I, Reich E P, Swenson K E, Flavell R A, Janeway C A, ;1995;Diabetes;44;326-9; 7533734