B6.129P2-Creb1tm3Gsc/Ieg

Status

Available to order

EMMA IDEM:02151
Citation informationRRID:IMSR_EM:02151 

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International strain nameB6.129P2-Creb1tm3Gsc/Ieg
Alternative nameCREB flox
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolCreb1tm3Gsc
Gene/Transgene symbolCreb1

Information from provider

ProviderGünther Schütz
Provider affiliationMolecular Biology of the Cell I, German Cancer Research Center
Genetic informationExon 10 of the Creb1 gene, encoding the first part of the bZIP domain, was flanked by loxP sites.
Phenotypic informationNone.
Breeding historyBackcrossed with C57BL/6 genetic background for more than 10 generations.
References
  • Disruption of CREB function in brain leads to neurodegeneration.;Mantamadiotis Theo, Lemberger Thomas, Bleckmann Susanne C, Kern Heidrun, Kretz Oliver, Martin Villalba Ana, Tronche François, Kellendonk Christoph, Gau Daniel, Kapfhammer Josef, Otto Christiane, Schmid Wolfgang, Schütz Günther, ;2002;Nature genetics;31;47-54; 11967539

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal myogenesis / MGI
  • abnormal muscle regeneration / MGI
  • small superior cervical ganglion / MGI
  • abnormal stellate ganglion morphology / MGI
  • abnormal lung development / MGI
  • abnormal cued conditioning behavior / MGI
  • abnormal spatial learning / MGI
  • abnormal temporal memory / MGI
  • abnormal contextual conditioning behavior / MGI
  • reduced long term potentiation / MGI
  • postnatal lethality / MGI
  • abnormal CNS synaptic transmission / MGI
  • decreased vertical activity / MGI
  • abnormal single cell response / MGI
  • small lung / MGI
  • abnormal lung vasculature morphology / MGI
  • decreased fetal size / MGI
  • muscle phenotype / MGI
  • impaired lung alveolus development / MGI
  • decreased survivor rate / MGI
  • abnormal behavioral response to addictive substance / MGI
  • decreased behavioral withdrawal response / MGI
  • pale lung / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • abnormal circadian behavior phase / MGI

Literature references

  • Disruption of CREB function in brain leads to neurodegeneration.;Mantamadiotis Theo, Lemberger Thomas, Bleckmann Susanne C, Kern Heidrun, Kretz Oliver, Martin Villalba Ana, Tronche François, Kellendonk Christoph, Gau Daniel, Kapfhammer Josef, Otto Christiane, Schmid Wolfgang, Schütz Günther, ;2002;Nature genetics;31;47-54; 11967539
  • A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction.;Fusco Salvatore, Ripoli Cristian, Podda Maria Vittoria, Ranieri Sofia Chiatamone, Leone Lucia, Toietta Gabriele, McBurney Michael W, Schütz Günther, Riccio Antonella, Grassi Claudio, Galeotti Tommaso, Pani Giovambattista, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;621-6; 22190495

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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