MGI phenotypes (gene matching)
FVB.129P2-Frat1tm1Brn Frat2tm2Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02143 |
| International strain name | FVB.129P2-Frat1tm1Brn Frat2tm2Brn/Cnrm |
| Alternative name | F1F2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Frat1tm1Brn, Frat2tm2Brn |
| Gene/Transgene symbol | Frat1, Frat2 |
Information from provider
| Provider | Renee van Amerongen |
| Provider affiliation | Netherlands Cancer Institute |
| Genetic information | Frat1 and Frat2 lie in a juxtaposed position. To obtain Frat1/2 double knock-out mice, Frat2 was targeted and replaced by a puromycin resistance cassette preceded by a PGK promoter in an ES cell clone already carrying a lacZ knock-in allele in Frat1. |
| Phenotypic information | Homozygous knock-out mice are viable, healthy and fertile without obvious abnormalities. |
| Breeding history | 129P2/OlaHsd mice were backcrossed onto FVB or C57BL/6 mice. Current generation is F12 backcross. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Frat is dispensable for canonical Wnt signaling in mammals.;van Amerongen Renée, Nawijn Martijn, Franca-Koh Jonathan, Zevenhoven John, van der Gulden Hanneke, Jonkers Jos, Berns Anton, ;2005;Genes & development;19;425-30; 15681612