MGI phenotypes (gene matching)
FVB.129P2-Frat1tm1Brn Frat2tm2Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02143 |
| Citation information | RRID:IMSR_EM:02143 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB.129P2-Frat1tm1Brn Frat2tm2Brn/Cnrm |
| Alternative name | F1F2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Frat1tm1Brn, Frat2tm2Brn |
| Gene/Transgene symbol | Frat1, Frat2 |
Information from provider
| Provider | Renee van Amerongen |
| Provider affiliation | Netherlands Cancer Institute |
| Genetic information | Frat1 and Frat2 lie in a juxtaposed position. To obtain Frat1/2 double knock-out mice, Frat2 was targeted and replaced by a puromycin resistance cassette preceded by a PGK promoter in an ES cell clone already carrying a lacZ knock-in allele in Frat1. |
| Phenotypic information | Homozygous knock-out mice are viable, healthy and fertile without obvious abnormalities. |
| Breeding history | 129P2/OlaHsd mice were backcrossed onto FVB or C57BL/6 mice. Current generation is F12 backcross. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Frat is dispensable for canonical Wnt signaling in mammals.;van Amerongen Renée, Nawijn Martijn, Franca-Koh Jonathan, Zevenhoven John, van der Gulden Hanneke, Jonkers Jos, Berns Anton, ;2005;Genes & development;19;425-30; 15681612