MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
FVB.129P2-Frat2tm1Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02141 |
| International strain name | FVB.129P2-Frat2tm1Brn/Cnrm |
| Alternative name | F2H |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Frat2tm1Brn |
| Gene/Transgene symbol | Frat2 |
Information from provider
| Provider | Renee van Amerongen |
| Provider affiliation | Netherlands Cancer Institute |
| Genetic information | The majority of the Frat2 coding sequence was replaced by a promoterless lacZ marker followed by a PGK-hygromycin resistance cassette. The lacZ expression pattern faithfully displays the endogenous Frat2 expression pattern. |
| Phenotypic information | Homozygous knockout mice are viable, healthy and fertile without obvious abnormalities. |
| Breeding history | 129P2/OlaHsd mice were backcrossed onto FVB mice. Current generation is F15 backcross. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Frat is dispensable for canonical Wnt signaling in mammals.;van Amerongen Renée, Nawijn Martijn, Franca-Koh Jonathan, Zevenhoven John, van der Gulden Hanneke, Jonkers Jos, Berns Anton, ;2005;Genes & development;19;425-30; 15681612