MGI phenotypes (gene matching)
B6.129-Atf1tm1Gsc/Ieg
| Status | Available to order |
| EMMA ID | EM:02133 |
| International strain name | B6.129-Atf1tm1Gsc/Ieg |
| Alternative name | ATF-1 -/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Atf1tm1Gsc |
| Gene/Transgene symbol | Atf1 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | Disruption of the Atf1 gene by homologous recombination of a construct containing lacZ and neo which results in the deletion of a portion of exon 3 and all of exons 4 through 7. The targeted region encoded amino acids 200 through 1380, corresponding to the protein kinase A and leucine zipper domains. |
| Phenotypic information | None. |
| Breeding history | More than 10 backcrosses on C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- Activating transcription factor 1 and CREB are important for cell survival during early mouse development.;Bleckmann Susanne C, Blendy Julie A, Rudolph Dorothea, Monaghan A Paula, Schmid Wolfgang, Schütz Günther, ;2002;Molecular and cellular biology;22;1919-25; 11865068
- Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1.;Seneviratne Anusha, Han Yumeng, Wong Eunice, Walter Edward R H, Jiang Lijun, Cave Luke, Long Nicholas J, Carling David, Mason Justin C, Haskard Dorian O, Boyle Joseph J, ;2020;Circulation research;127;928-944; 32611235