B6.FVB-Tg(Aqp2-icre)1Gsc/Ieg
| Status | Available to order |
| EMMA ID | EM:02127 |
| International strain name | B6.FVB-Tg(Aqp2-icre)1Gsc/Ieg |
| Alternative name | AQP2 Cre 2-copy line |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Aqp2-icre)1Gsc |
| Gene/Transgene symbol | Tg(Aqp2-icre)1Gsc |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | An open reading frame encoding the cre recombinase was introduced by homologous recombination in bacteria at the start codon of the Aqp2 gene on a PAC containing a 125 kb upstream region and a 31 kb downstream region of the mouse Aqp2 gene. |
| Phenotypic information | None. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Literature references
- Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor.;Ronzaud Caroline, Loffing Johannes, Bleich Markus, Gretz Norbert, Gröne Hermann-Josef, Schütz Günther, Berger Stefan, ;2007;Journal of the American Society of Nephrology : JASN;18;1679-87; 17475815
- Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus.;Petrillo Federica, Iervolino Anna, Angrisano Tiziana, Jelen Sabina, Costanzo Vincenzo, D'Acierno Mariavittoria, Cheng Lei, Wu Qi, Guerriero Ilaria, Mazzarella Maria Cristina, De Falco Alfonso, D'Angelo Fulvio, Ceccarelli Michele, Caraglia Michele, Capasso Giovambattista, Fenton Robert A, Trepiccione Francesco, ;2021;Journal of the American Society of Nephrology : JASN;32;1339-1354; 33727367