B6.129P2-Tg(Dyrk1a)189N3Yah/JmdOrl
| Status | Available to order |
| EMMA ID | EM:02119 |
| Citation information | RRID:IMSR_EM:02119 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Tg(Dyrk1a)189N3Yah/JmdOrl |
| Alternative name | 189-N3 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Dyrk1a)189N3Yah |
| Gene/Transgene symbol | Tg(Dyrk1a)189N3Yah |
Information from provider
| Provider | Jean Maurice Delabar |
| Provider affiliation | EA3508- IFR117- Univ Paris7 |
| Genetic information | Electroporation of a 200kb BAC clone containing the full murine Dyrk1a gene in ES cells (collaboration with Dr Y Herault). |
| Phenotypic information | Brain defect: volume increase particularly of the ventral part of the brain. |
| Breeding history | Backcrossed to C57BL/6, N=5 |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.;Branchi Igor, Bichler Zoë, Minghetti Luisa, Delabar Jean Maurice, Malchiodi-Albedi Fiorella, Gonzalez Marie-Claude, Chettouh Zoubidda, Nicolini Alessia, Chabert Caroline, Smith Desmond J, Rubin Edward M, Migliore-Samour Danièle, Alleva Enrico, ;2004;Journal of neuropathology and experimental neurology;63;429-40; 15198122
- Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.;Duchon Arnaud, Del Mar Muniz Moreno Maria, Martin Lorenzo Sandra, Silva de Souza Marcia Priscilla, Chevalier Claire, Nalesso Valérie, Meziane Hamid, Loureiro de Sousa Paulo, Noblet Vincent, Armspach Jean-Paul, Brault Veronique, Herault Yann, ;2021;Human molecular genetics;30;771-788; 33693642