C3El.Cg-Gpi1b-m2Neu/Ieg

Status

Available to order

EMMA IDEM:02118
International strain nameC3El.Cg-Gpi1b-m2Neu/Ieg
Alternative nameGPI27201
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolGpi1b-m2Neu
Gene/Transgene symbolGpi1

Information from provider

ProviderWalter Pretsch
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationPoint mutation ATG -> GTG resulting in an amino acid alteration Met -> Val at position 84.
Phenotypic informationGlucose-6-phosphate isomerase deficiency (approximately 60% residual activity in heterozygous and approximately 20% residual activity in homozygous mutants) in blood and other organs.
Breeding historyC3H/El (46th generation).
References
  • Glucose phosphate isomerase enzyme-activity mutants in Mus musculus: genetical and biochemical characterization.;Pretsch W, Merkle S, ;1990;Biochemical genetics;28;97-110; 2344351
  • Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease.;Merkle S, Pretsch W, ;1993;Blood;81;206-13; 8417789

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • decreased hematocrit / MGI
  • decreased body weight / MGI
  • abnormal erythrocyte morphology / MGI
  • increased mean corpuscular volume / MGI
  • reticulocytosis / MGI
  • increased heart weight / MGI
  • decreased erythrocyte cell number / MGI
  • increased liver weight / MGI
  • abnormal erythrocyte physiology / MGI
  • abnormal erythrocyte osmotic lysis / MGI
  • increased spleen weight / MGI
  • increased circulating bilirubin level / MGI
  • increased circulating glucose level / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • increased lung weight / MGI
  • decreased mean corpuscular hemoglobin concentration / MGI
  • lethality, incomplete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • decreased body weight / MGI
  • prenatal lethality / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal erythrocyte morphology / MGI
  • increased mean corpuscular volume / MGI
  • reticulocytosis / MGI
  • increased heart weight / MGI
  • decreased erythrocyte cell number / MGI
  • increased liver weight / MGI
  • abnormal erythrocyte physiology / MGI
  • abnormal erythrocyte osmotic lysis / MGI
  • increased spleen weight / MGI
  • increased circulating bilirubin level / MGI
  • increased circulating glucose level / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • increased lung weight / MGI
  • decreased mean corpuscular hemoglobin concentration / MGI
  • lethality, incomplete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality between implantation and placentation, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI

Literature references

  • Glucose phosphate isomerase enzyme-activity mutants in Mus musculus: genetical and biochemical characterization.;Pretsch W, Merkle S, ;1990;Biochemical genetics;28;97-110; 2344351
  • Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease.;Merkle S, Pretsch W, ;1993;Blood;81;206-13; 8417789

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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