MGI phenotypes (allele matching)
- immune system phenotype / MGI
STOCK Igh-8tm2.1Aak/Orl
| Status | Available to order |
| EMMA ID | EM:02109 |
| Citation information | RRID:IMSR_EM:02109 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Igh-8tm2.1Aak/Orl |
| Alternative name | pAp-gamma3 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Igh-8tm2.1Aak |
| Gene/Transgene symbol | Igh-8 |
Information from provider
| Provider | Ahmed Amine Khamlichi |
| Provider affiliation | CNRS UMR 6101 |
| Genetic information | Targeting construct is derived from 129 DNA. The insertion brings polyadenylation and pause sites upstream of Sgamma3 region. All elements have been left intact. |
| Phenotypic information | Inhibition of germline transcription elongation. A specific defect in class switching to IgG3. |
| Breeding history | Bred with C57BL/6 for several generations. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751