MGI phenotypes (allele matching)
STOCK Ighmtm1.1Aak/Orl
| Status | Available to order |
| EMMA ID | EM:02108 |
| Citation information | RRID:IMSR_EM:02108 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Ighmtm1.1Aak/Orl |
| Alternative name | pAp-mu |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Ighmtm1.1Aak |
| Gene/Transgene symbol | Ighm |
Information from provider
| Provider | Ahmed Amine Khamlichi |
| Provider affiliation | CNRS UMR 6101 |
| Genetic information | Targeting construct is derived from 129 DNA. The insertion brings polyadenylation and pause sites upstream of Smu region. All elements have been left intact. |
| Phenotypic information | Alteration of germline transcription elongation. A general defect in class switching to all isotypes. |
| Breeding history | Bred with C57BL/6 for several generations. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal agammaglobulinemia / Orphanet_33110
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal spleen morphology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- arrested B cell differentiation / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal antigen presentation / MGI
- kidney inflammation / MGI
- abnormal lymphatic vessel morphology / MGI
- abnormal respiratory system physiology / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- small lymph nodes / MGI
- abnormal spleen white pulp morphology / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen germinal center morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal spleen marginal sinus morphology / MGI
- increased susceptibility to viral infection / MGI
- abnormal B cell physiology / MGI
- decreased immunoglobulin level / MGI
- abnormal complement pathway / MGI
- impaired complement classical pathway / MGI
- decreased IgE level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- abnormal immune serum protein physiology / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- increased susceptibility to induced arthritis / MGI
- increased autoantibody level / MGI
- abnormal compact bone morphology / MGI
- insulitis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- abnormal class switch recombination / MGI
- decreased spleen weight / MGI
- increased B-1 B cell number / MGI
- decreased B-1 B cell number / MGI
- increased osteoclast cell number / MGI
- increased B cell number / MGI
- decreased B cell number / MGI
- abnormal immature B cell morphology / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- decreased B cell proliferation / MGI
- abnormal T cell proliferation / MGI
- decreased T cell proliferation / MGI
- increased B cell proliferation / MGI
- decreased susceptibility to injury / MGI
- immune system phenotype / MGI
- respiratory system phenotype / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal T cell number / MGI
- absent B cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased plasma cell number / MGI
- abnormal plasma cell differentiation / MGI
- decreased dendritic cell number / MGI
- decreased Peyer's patch number / MGI
- small Peyer's patches / MGI
- abnormal B-1a B cell morphology / MGI
- abnormal mature B cell morphology / MGI
- decreased follicular B cell number / MGI
- increased marginal zone B cell number / MGI
- decreased marginal zone B cell number / MGI
- increased pro-B cell number / MGI
- decreased transitional stage B cell number / MGI
- abnormal follicular dendritic cell antigen presentation / MGI
- absent follicular dendritic cells / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- absent mature B cells / MGI
- absent immature B cells / MGI
- decreased immature B cell number / MGI
- abnormal B cell activation / MGI
- abnormal spleen marginal zone macrophage morphology / MGI
- abnormal metallophilic macrophage morphology / MGI
- abnormal CD8 positive, alpha-beta intraepithelial T cell morphology / MGI
- abnormal spleen B cell follicle morphology / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased IgG2a level / MGI
- increased IgG3 level / MGI
- abnormal splenic cell ratio / MGI
- decreased trabecular bone thickness / MGI
- decreased compact bone volume / MGI
Literature references
- Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751