CByIco.129S7-Ifng^tm1Ts/Cnrm

Status	Available to order
EMMA ID	EM:02106
International strain name	CByIco.129S7-Ifng^tm1Ts/Cnrm
Alternative name	BALB/cByJIco IFNg-/-
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Ifng^tm1Ts
Gene/Transgene symbol	Ifng

Information from provider

Provider	Ursula Günthert
Provider affiliation	Institut für Pathologie, University of Basel
Genetic information	Insertion of a neomycin gene into exon 2 of Ifng (interferon gamma) gene, which introduced a termination codon after the first 30 amino acids of the mature protein.
Phenotypic information	Ifng (interferon gamma) -/-: reduced macrophage function with impaired production of antimicrobial products; reduced MHCII expression and abnormal natural killer cell development.
Breeding history	Backcrossed for 10 generations onto BALB/cByJIco.
References	Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.;Dalton D K, Pitts-Meek S, Keshav S, Figari I S, Bradley A, Stewart T A, ;1993;Science (New York, N.Y.);259;1739-42; 8456300

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

IMPC phenotypes (gene matching)

preweaning lethality, complete penetrance / IMPC
increased hematocrit / IMPC
embryonic lethality prior to organogenesis / IMPC
embryonic lethality prior to tooth bud stage / IMPC
abnormal lung morphology / IMPC
decreased prepulse inhibition / IMPC

MGI phenotypes (allele matching)

increased leukocyte cell number / MGI
increased monocyte cell number / MGI
extramedullary hematopoiesis / MGI
increased granulocyte number / MGI
abnormal spleen morphology / MGI
enlarged spleen / MGI
abnormal response to new environment / MGI
abnormal humoral immune response / MGI
stomach inflammation / MGI
abnormal spleen red pulp morphology / MGI
abnormal spleen white pulp morphology / MGI
abnormal dendritic cell physiology / MGI
increased susceptibility to bacterial infection / MGI
abnormal dendritic cell antigen presentation / MGI
abnormal immunoglobulin level / MGI
abnormal type IV hypersensitivity reaction / MGI
glomerulonephritis / MGI
decreased vertical activity / MGI
albuminuria / MGI
abnormal cytokine secretion / MGI
abnormal redox activity / MGI
increased fear-related response / MGI
abnormal nitric oxide homeostasis / MGI
decreased length of allograft survival / MGI
abnormal immune tolerance / MGI
increased susceptibility to parasitic infection / MGI
abnormal response to injury / MGI
decreased susceptibility to injury / MGI
abnormal Langerhans cell physiology / MGI
immune system phenotype / MGI
increased susceptibility to type IV hypersensitivity reaction / MGI
increased NK T cell number / MGI
enlarged mesenteric lymph nodes / MGI
decreased interferon-gamma secretion / MGI
increased circulating interleukin-6 level / MGI
decreased interleukin-10 secretion / MGI
increased interleukin-12 secretion / MGI
increased interleukin-4 secretion / MGI
pale spleen / MGI
skeletal muscle fibrosis / MGI
abnormal urine homeostasis / MGI
increased sensitivity to xenobiotic induced morbidity/mortality / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
abnormal circulating cytokine level / MGI
abnormal dendritic cell chemotaxis / MGI
increased susceptibility to parasitic infection induced morbidity/mortality / MGI
abnormal macrophage chemotaxis / MGI
impaired skeletal muscle regeneration / MGI
abnormal inflammatory response / MGI
decreased litter size / MGI
abnormal adaptive immunity / MGI
abnormal macrophage physiology / MGI
abnormal maternal decidual layer morphology / MGI
decreased susceptibility to parasitic infection / MGI
abnormal cytotoxic T cell physiology / MGI
abnormal uterine NK cell morphology / MGI
abnormal uterine NK cell physiology / MGI
increased uterine NK cell number / MGI
decreased tumor latency / MGI
altered tumor pathology / MGI
abnormal NK cell physiology / MGI
abnormal pancreatic beta cell physiology / MGI
decreased susceptibility to autoimmune diabetes / MGI
increased T cell derived lymphoma incidence / MGI
increased sarcoma incidence / MGI
premature death / MGI
increased susceptibility to viral infection / MGI
abnormal B cell physiology / MGI
increased IgE level / MGI
abnormal response to infection / MGI
abnormal response to transplant / MGI
increased CD8-positive, alpha-beta T cell number / MGI
decreased IgG2a level / MGI
decreased IgG3 level / MGI
increased IgG1 level / MGI
increased interleukin-10 secretion / MGI
increased interleukin-2 secretion / MGI
increased interleukin-5 secretion / MGI
abnormal lymph node cell ratio / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI
increased lymphoma incidence / MGI
neoplasm / MGI
increased lung adenocarcinoma incidence / MGI
increased susceptibility to experimental autoimmune encephalomyelitis / MGI
increased tumor latency / MGI
altered susceptibility to autoimmune disorder / MGI
increased metastatic potential / MGI
decreased tumor incidence / MGI
abnormal MHC II cell surface expression on macrophages / MGI
abnormal skin physiology / MGI
increased splenocyte proliferation / MGI
decreased susceptibility to parasitic infection induced morbidity/mortality / MGI
alveolar process atrophy / MGI
impaired natural killer cell mediated cytotoxicity / MGI
corneal vascularization / MGI
decreased susceptibility to type IV hypersensitivity reaction / MGI
increased interleukin-17 secretion / MGI
abnormal cytokine level / MGI
altered susceptibility to infection / MGI
decreased inflammatory response / MGI
increased airway responsiveness / MGI
decreased airway responsiveness / MGI
decreased IgE level / MGI
decreased IgM level / MGI
decreased IgA level / MGI
decreased immunoglobulin level / MGI
decreased autoantibody level / MGI
decreased anti-nuclear antigen antibody level / MGI
decreased anti-double stranded DNA antibody level / MGI
decreased susceptibility to autoimmune disorder / MGI
decreased IgG2b level / MGI
decreased IgG level / MGI
decreased physiological sensitivity to xenobiotic / MGI

MGI phenotypes (gene matching)

increased leukocyte cell number / MGI
increased monocyte cell number / MGI
decreased leukocyte cell number / MGI
extramedullary hematopoiesis / MGI
abnormal erythropoiesis / MGI
increased granulocyte number / MGI
decreased bone marrow cell number / MGI
abnormal spleen morphology / MGI
enlarged spleen / MGI
increased metastatic potential / MGI
abnormal response to new environment / MGI
anemia / MGI
impaired hematopoiesis / MGI
hepatic necrosis / MGI
altered susceptibility to infection / MGI
abnormal humoral immune response / MGI
decreased IgG level / MGI
decreased IgM level / MGI
decreased IgA level / MGI
abnormal T cell activation / MGI
abnormal inflammatory response / MGI
stomach inflammation / MGI
decreased inflammatory response / MGI
decreased litter size / MGI
increased airway responsiveness / MGI
neoplasm / MGI
increased T cell derived lymphoma incidence / MGI
increased lung adenocarcinoma incidence / MGI
increased sarcoma incidence / MGI
decreased tumor incidence / MGI
premature death / MGI
abnormal B cell differentiation / MGI
no abnormal phenotype detected / MGI
decreased airway responsiveness / MGI
abnormal lymph node morphology / MGI
abnormal spleen red pulp morphology / MGI
abnormal spleen white pulp morphology / MGI
abnormal dendritic cell physiology / MGI
abnormal bone marrow cell morphology/development / MGI
increased susceptibility to bacterial infection / MGI
abnormal proerythroblast morphology / MGI
increased susceptibility to viral infection / MGI
abnormal adaptive immunity / MGI
altered susceptibility to autoimmune disorder / MGI
abnormal macrophage physiology / MGI
abnormal dendritic cell antigen presentation / MGI
abnormal B cell physiology / MGI
decreased immunoglobulin level / MGI
abnormal immunoglobulin level / MGI
decreased IgE level / MGI
increased IgE level / MGI
abnormal type IV hypersensitivity reaction / MGI
glomerulonephritis / MGI
decreased vertical activity / MGI
albuminuria / MGI
decreased erythrocyte cell number / MGI
abnormal cytokine secretion / MGI
no phenotypic analysis / MGI
thrombocytopenia / MGI
abnormal redox activity / MGI
increased fear-related response / MGI
abnormal pancreatic beta cell physiology / MGI
spleen atrophy / MGI
thymus atrophy / MGI
abnormal female reproductive system physiology / MGI
decreased autoantibody level / MGI
abnormal nitric oxide homeostasis / MGI
abnormal maternal decidual layer morphology / MGI
decreased length of allograft survival / MGI
decreased anti-nuclear antigen antibody level / MGI
decreased anti-double stranded DNA antibody level / MGI
increased susceptibility to experimental autoimmune encephalomyelitis / MGI
decreased susceptibility to autoimmune diabetes / MGI
abnormal hematopoietic stem cell morphology / MGI
increased hematopoietic stem cell number / MGI
abnormal immune tolerance / MGI
increased T cell number / MGI
abnormal response to infection / MGI
decreased susceptibility to parasitic infection / MGI
increased susceptibility to parasitic infection / MGI
abnormal MHC II cell surface expression on macrophages / MGI
impaired natural killer cell mediated cytotoxicity / MGI
abnormal cytotoxic T cell physiology / MGI
pancytopenia / MGI
abnormal response to injury / MGI
decreased susceptibility to injury / MGI
decreased susceptibility to autoimmune disorder / MGI
abnormal Langerhans cell physiology / MGI
immune system phenotype / MGI
abnormal skin physiology / MGI
corneal vascularization / MGI
decreased susceptibility to type IV hypersensitivity reaction / MGI
increased susceptibility to type IV hypersensitivity reaction / MGI
abnormal response to transplant / MGI
decreased apoptosis / MGI
increased NK T cell number / MGI
abnormal uterine NK cell morphology / MGI
increased CD8-positive, alpha-beta T cell number / MGI
decreased pre-B cell number / MGI
decreased mature B cell number / MGI
decreased megakaryocyte cell number / MGI
enlarged mesenteric lymph nodes / MGI
decreased IgG2a level / MGI
decreased IgG2b level / MGI
decreased IgG3 level / MGI
increased IgG1 level / MGI
decreased interferon-gamma secretion / MGI
increased circulating interleukin-6 level / MGI
increased interleukin-10 secretion / MGI
decreased interleukin-10 secretion / MGI
increased interleukin-12 secretion / MGI
increased interleukin-17 secretion / MGI
increased interleukin-2 secretion / MGI
increased interleukin-4 secretion / MGI
increased interleukin-5 secretion / MGI
abnormal cytokine level / MGI
decreased common myeloid progenitor cell number / MGI
abnormal lymph node cell ratio / MGI
decreased physiological sensitivity to xenobiotic / MGI
decreased erythroid progenitor cell number / MGI
abnormal uterine NK cell physiology / MGI
pale spleen / MGI
increased splenocyte proliferation / MGI
increased uterine NK cell number / MGI
increased nucleated erythrocyte cell number / MGI
skeletal muscle fibrosis / MGI
abnormal urine homeostasis / MGI
increased sensitivity to xenobiotic induced morbidity/mortality / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI
increased tumor latency / MGI
abnormal circulating cytokine level / MGI
decreased tumor latency / MGI
altered tumor pathology / MGI
abnormal dendritic cell chemotaxis / MGI
increased susceptibility to parasitic infection induced morbidity/mortality / MGI
decreased susceptibility to parasitic infection induced morbidity/mortality / MGI
abnormal macrophage chemotaxis / MGI
abnormal NK cell physiology / MGI
increased erythroblast number / MGI
increased lymphoma incidence / MGI
impaired skeletal muscle regeneration / MGI
decreased myeloid cell number in bone marrow / MGI
decreased granulocyte monocyte progenitor cell number / MGI
decreased megakaryocyte-erythroid progenitor cell number / MGI
alveolar process atrophy / MGI

Literature references

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.;Dalton D K, Pitts-Meek S, Keshav S, Figari I S, Bradley A, Stewart T A, ;1993;Science (New York, N.Y.);259;1739-42; 8456300

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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CByIco.129S7-Ifngtm1Ts/Cnrm