- behavior/neurological phenotype / MGI
B6;129P2-Del(10Prmt2-Cstb)4Yah/Orl
Status | Available to order |
EMMA ID | EM:02099 |
International strain name | B6;129P2-Del(10Prmt2-Cstb)4Yah/Orl |
Alternative name | Del(Prmt2-Cstb)Ms4Yah |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Del(10Prmt2-Cstb)4Yah, |
Gene/Transgene symbol | Del(10Prmt2-Cstb)4Yah |
Information from provider
Provider | Yann HERAULT |
Provider affiliation | TAAM-CDTA UPS44, Institut de Transgenose, INTRAGENE |
Genetic information | Deletion of the region between the Prmt2 (synonym=Hrmt1l1) and Cstb genes engineered using MICER in ES (HM-1) cells. |
Phenotypic information | Homozygotes: early embryonic lethal. Heterozygotes: no major defects. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.;Duchon Arnaud, Pothion Stéphanie, Brault Véronique, Sharp Andrew J, Tybulewicz Victor L J, Fisher Elizabeth M C, Herault Yann, ;2011;Behavioural brain research;217;271-81; 21047530
- Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310
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