STOCK Ret^tm1Cos/Kctt

Status	Available to order
EMMA ID	EM:02081
International strain name	STOCK Ret^tm1Cos/Kctt
Alternative name	Ret KO
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Ret^tm1Cos
Gene/Transgene symbol	Ret

Information from provider

Provider	Christel Baudet
Provider affiliation	Universite Bordeaux 2
Genetic information	Ubiquitous deletion of exons 12 and 13 after crossing the conditional Ret floxed allele with a cre-deleter strain, thereby generating a 'kinase dead receptor'. An FRT site is left in the genome after the excision of the FRT flanked neomycin cassette by flp recombinase.
Phenotypic information	Homozygous mice die at birth of kidney agenesis. Heterozygous mice are viable and fertile.
References	Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.;Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V, ;1994;Nature;367;380-3; 8114940 Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.;Schuchardt A, D'Agati V, Pachnis V, Costantini F, ;1996;Development (Cambridge, England);122;1919-29; 8674430 Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI allele-associated human disease models

Hirschsprung's disease / DOID:10487

Orphanet associated rare diseases, based on orthologous gene matching

Renal agenesis, bilateral / Orphanet_1848
Multiple endocrine neoplasia type 2B / Orphanet_247709
Familial medullary thyroid carcinoma / Orphanet_99361
Renal agenesis, unilateral / Orphanet_93100
Haddad syndrome / Orphanet_99803
Multiple endocrine neoplasia type 2A / Orphanet_247698
Hirschsprung disease / Orphanet_388

MGI phenotypes (allele matching)

abnormal enteric neuron morphology / MGI
intestinal hypoperistalsis / MGI
abnormal neurotransmitter secretion / MGI
single kidney / MGI
decreased renal glomerulus number / MGI
absent kidney / MGI
abnormal ureter morphology / MGI
absent superior cervical ganglion / MGI
abnormal stellate ganglion morphology / MGI
absent enteric neurons / MGI
abnormal lung development / MGI
abnormal kidney morphology / MGI
dilated renal tubules / MGI
small kidney / MGI
dilated renal glomerular capsule / MGI
abnormal ureter development / MGI
abnormal cardiac ganglion morphology / MGI
absent ureter / MGI
abnormal kidney collecting duct morphology / MGI
cardiovascular system phenotype / MGI
abnormal parasympathetic postganglionic fiber morphology / MGI
abnormal mesonephros morphology / MGI
abnormal branching involved in ureteric bud morphogenesis / MGI
abnormal ureteric bud elongation / MGI
abnormal ureteric bud invasion / MGI
abnormal metanephric mesenchyme morphology / MGI
abnormal kidney mesenchyme morphology / MGI
neonatal lethality, complete penetrance / MGI
increased metanephric mesenchyme apoptosis / MGI
absent nephrogenic zone / MGI
blind ureter / MGI
oligohydramnios / MGI
abnormal enteric neural crest cell migration / MGI
endocrine/exocrine gland phenotype / MGI
abnormal enteric nervous system morphology / MGI
abnormal enteric ganglia morphology / MGI
neoplasm / MGI
reproductive system phenotype / MGI
aganglionic megacolon / MGI
renal hypoplasia / MGI

MGI phenotypes (gene matching)

increased cell proliferation / MGI
abnormal large intestine morphology / MGI
abnormal colon morphology / MGI
abnormal small intestine morphology / MGI
hydronephrosis / MGI
absent kidney / MGI
abnormal kidney development / MGI
abnormal ureter morphology / MGI
abnormal urinary bladder morphology / MGI
abnormal adrenal gland morphology / MGI
abnormal thyroid gland morphology / MGI
decreased motor neuron number / MGI
abnormal motor neuron innervation pattern / MGI
abnormal sympathetic ganglion morphology / MGI
absent superior cervical ganglion / MGI
small superior cervical ganglion / MGI
abnormal stellate ganglion morphology / MGI
abnormal sympathetic neuron morphology / MGI
abnormal enteric nervous system morphology / MGI
abnormal enteric ganglia morphology / MGI
abnormal enteric neuron morphology / MGI
absent enteric neurons / MGI
abnormal innervation pattern to muscle / MGI
abnormal neuromuscular synapse morphology / MGI
seminiferous tubule degeneration / MGI
arrest of spermatogenesis / MGI
abnormal spermatogenesis / MGI
abnormal lung development / MGI
decreased body weight / MGI
distended abdomen / MGI
postnatal growth retardation / MGI
male infertility / MGI
neoplasm / MGI
increased pheochromocytoma incidence / MGI
neonatal lethality / MGI
premature death / MGI
abnormal kidney morphology / MGI
no abnormal phenotype detected / MGI
abnormal innervation / MGI
muscular atrophy / MGI
cryptorchism / MGI
dilated renal tubules / MGI
abnormal vas deferens morphology / MGI
abnormal neuron morphology / MGI
aganglionic megacolon / MGI
small kidney / MGI
no phenotypic analysis / MGI
abnormal gastrocnemius morphology / MGI
increased neuron apoptosis / MGI
decreased neuron apoptosis / MGI
abnormal intestinal peristalsis / MGI
intestinal hypoperistalsis / MGI
abnormal hypaxial muscle morphology / MGI
renal hypoplasia / MGI
increased thyroid adenoma incidence / MGI
thyroid gland hyperplasia / MGI
large ureter / MGI
dilated ureter / MGI
ureter obstruction / MGI
ureter stenosis / MGI
ectopic kidney / MGI
single kidney / MGI
abnormal kidney medulla development / MGI
nervous system phenotype / MGI
dilated renal glomerular capsule / MGI
abnormal ureter development / MGI
kidney cysts / MGI
abnormal cardiac ganglion morphology / MGI
absent ureter / MGI
abnormal submandibular gland morphology / MGI
abnormal defecation / MGI
abnormal feces composition / MGI
decreased kidney weight / MGI
abnormal muscle spindle morphology / MGI
decreased renal glomerulus number / MGI
abnormal kidney collecting duct morphology / MGI
impaired branching involved in ureteric bud morphogenesis / MGI
kidney atrophy / MGI
glomerulosclerosis / MGI
abnormal renal glomerulus morphology / MGI
renal/urinary system phenotype / MGI
endocrine/exocrine gland phenotype / MGI
digestive/alimentary phenotype / MGI
cardiovascular system phenotype / MGI
immune system phenotype / MGI
reproductive system phenotype / MGI
abnormal neurotransmitter secretion / MGI
abnormal enzyme/coenzyme activity / MGI
abnormal ureteric bud morphology / MGI
abnormal adrenal medulla morphology / MGI
adrenergic chromaffin cell hyperplasia / MGI
adrenal cortical hyperplasia / MGI
abnormal sympathetic postganglionic fiber morphology / MGI
abnormal parasympathetic postganglionic fiber morphology / MGI
abnormal pterygopalatine ganglion morphology / MGI
abnormal prevertebral ganglion morphology / MGI
abnormal mesonephros morphology / MGI
distended ileum / MGI
absent kidney cortex / MGI
abnormal neuron differentiation / MGI
increased ganglioneuroma incidence / MGI
mortality/aging / MGI
ectopic ureteric bud / MGI
abnormal branching involved in ureteric bud morphogenesis / MGI
abnormal ureteric bud elongation / MGI
abnormal ureteric bud invasion / MGI
abnormal metanephric mesenchyme morphology / MGI
abnormal kidney mesenchyme morphology / MGI
postnatal lethality, complete penetrance / MGI
postnatal lethality, incomplete penetrance / MGI
neonatal lethality, complete penetrance / MGI
perinatal lethality, complete penetrance / MGI
preweaning lethality, incomplete penetrance / MGI
increased kidney apoptosis / MGI
increased metanephric mesenchyme apoptosis / MGI
renal cast / MGI
absent nephrogenic zone / MGI
ectopic testis / MGI
absent kidney medulla / MGI
ectopic ovary / MGI
blind ureter / MGI
oligohydramnios / MGI
abnormal enteric neural crest cell morphology / MGI
absent enteric neural crest cell / MGI
abnormal enteric neural crest cell migration / MGI

Literature references

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.;Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V, ;1994;Nature;367;380-3; 8114940
Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.;Schuchardt A, D'Agati V, Pachnis V, Costantini F, ;1996;Development (Cambridge, England);122;1919-29; 8674430
Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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STOCK Rettm1Cos/Kctt