MGI phenotypes (allele matching)
B6.129P2-Igh-Jtm1Cgn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02078 |
| International strain name | B6.129P2-Igh-Jtm1Cgn/Cnrm |
| Alternative name | B6-Igh-JHT |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Igh-Jtm1Cgn |
| Gene/Transgene symbol | Igh-J |
Information from provider
| Provider | Klaus Rajeswky |
| Provider affiliation | Harvard Medical School |
| Genetic information | Deletion of JH1, 2, 3 and 4 elements including the DQ52 gene segment and the heavy chain enhancer. |
| Phenotypic information | B cell deficiency. Mice are immunosuppressed, they show an impaired pathogen defense. |
| Breeding history | Backcrossing to C57BL/6 (N=10); inbred by intercross of homozygous pups. Under good hygienic conditions normal breeding performance. In general fewer females are born. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- spleen hypoplasia / MGI
- arrested B cell differentiation / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- abnormal immune serum protein physiology / MGI
- increased pre-B cell number / MGI
- increased late pro-B cell number / MGI
- increased susceptibility to induced arthritis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal B cell morphology / MGI
- decreased spleen weight / MGI
- increased B-1 B cell number / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal T cell number / MGI
- absent B cells / MGI
- decreased B-1a cell number / MGI
- abnormal marginal zone B cell morphology / MGI
- increased marginal zone B cell number / MGI
- increased pro-B cell number / MGI
- decreased transitional stage B cell number / MGI
- decreased pre-B cell number / MGI
- increased mature B cell number / MGI
- decreased mature B cell number / MGI
- absent mature B cells / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- decreased IgG1 level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- abnormal B cell receptor editing / MGI
- decreased transitional stage T1 B cell number / MGI
- decreased transitional stage T2 B cell number / MGI
Literature references
- Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.;Gu H, Zou Y R, Rajewsky K, ;1993;Cell;73;1155-64; 8513499