IMPC phenotypes (gene matching)
B6.129P2-Cd19tm1(cre)Cgn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02077 |
| International strain name | B6.129P2-Cd19tm1(cre)Cgn/Cnrm |
| Alternative name | B6-CD19-Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Cd19tm1(cre)Cgn |
| Gene/Transgene symbol | Cd19 |
Information from provider
| Provider | Klaus Rajeswky |
| Provider affiliation | Harvard Medical School |
| Genetic information | Original targeted mutation for the specific expression of cre recombinase in B-lymphocytes throughout development and differentiation. In-frame insertion of a cre recombinase gene into the first coding exon of the Cd19 gene, followed by an frt-flanked neomycin cassette. The endogenous Cd19 promoter drives the cre recombinase expression. |
| Phenotypic information | Original strain for cre recombinase expression throughout B-lymphocyte development and differentiation. Heterozygous mice are normal and can be crossed to mice carrying floxed gene targets, for specific in vivo deletion in B-lymphocytes. |
| Breeding history | Backcrossed to C57BL/6 (10 generations) |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Common variable immunodeficiency / Orphanet_1572
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- demyelination / MGI
- thick dermal layer / MGI
- abnormal humoral immune response / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal B cell physiology / MGI
- abnormal immunoglobulin level / MGI
- decreased IgE level / MGI
- decreased anti-nuclear antigen antibody level / MGI
- decreased anti-double stranded DNA antibody level / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased B cell proliferation / MGI
- increased susceptibility to injury / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-4 level / MGI
- decreased interleukin-10 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- skin fibrosis / MGI
Literature references
- B lymphocyte-specific, Cre-mediated mutagenesis in mice.;Rickert R C, Roes J, Rajewsky K, ;1997;Nucleic acids research;25;1317-8; 9092650