IMPC phenotypes (gene matching)
B6.129P2-Parltm1Bdes/Ieg
| Status | Available to order |
| EMMA ID | EM:02076 |
| International strain name | B6.129P2-Parltm1Bdes/Ieg |
| Alternative name | Parl conditional KO |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Parltm1Bdes |
| Gene/Transgene symbol | Parl |
Information from provider
| Provider | Bart De Stropper |
| Provider affiliation | Flanders interuniversitary institute for biotechnologies (VIB) |
| Genetic information | LoxP sequences were inserted into intron 2 and intron 3 of Parl gene thus generating the Parl conditional allele Parltm1Bdes. |
| Phenotypic information | None. |
| Breeding history | The colony has been backcrossed 8 times to C57BL/6. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
MGI phenotypes (gene matching)
- kyphosis / MGI
- abnormal male reproductive system morphology / MGI
- small testis / MGI
- postnatal growth retardation / MGI
- respiratory distress / MGI
- premature death / MGI
- neurodegeneration / MGI
- muscular atrophy / MGI
- cryptorchism / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- abnormal nervous system physiology / MGI
- spleen atrophy / MGI
- thymus atrophy / MGI
- abnormal uterine environment / MGI
- decreased skeletal muscle mass / MGI
- small epididymis / MGI
- abnormal B cell morphology / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased double-positive T cell number / MGI
- cachexia / MGI
- abnormal nerve conduction / MGI
- abnormal cell physiology / MGI
- abnormal mitochondrial physiology / MGI
- increased T cell apoptosis / MGI
- decreased skeletal muscle fiber diameter / MGI
Literature references
- Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.;Cipolat Sara, Rudka Tomasz, Hartmann Dieter, Costa Veronica, Serneels Lutgarde, Craessaerts Katleen, Metzger Kristine, Frezza Christian, Annaert Wim, D'Adamio Luciano, Derks Carmen, Dejaegere Tim, Pellegrini Luca, D'Hooge Rudi, Scorrano Luca, De Strooper Bart, ;2006;Cell;126;163-75; 16839884