IMPC phenotypes (gene matching)
B6.129P2(Cg)-Parltm1.1Bdes/Ieg
| Status | Available to order |
| EMMA ID | EM:02075 |
| International strain name | B6.129P2(Cg)-Parltm1.1Bdes/Ieg |
| Alternative name | Parl |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Parltm1.1Bdes |
| Gene/Transgene symbol | Parl |
Information from provider
| Provider | Bart De Stropper |
| Provider affiliation | Flanders interuniversitary institute for biotechnologies (VIB) |
| Genetic information | Cre recombinase-mediated recombination in mice carrying the Parltm1Bdes allele (Parl conditional; EMMA strain ID EM:02076), resulted in the excision of exon 2, thus generating a Parl null allele (Parltm1.1Bdes). |
| Phenotypic information | See: Cipolat S et al., "Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling." Cell 2006 Jul 14;126(1):163-75. |
| Breeding history | The colony has been backcrossed 10 times. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
- kyphosis / MGI
- abnormal male reproductive system morphology / MGI
- small testis / MGI
- postnatal growth retardation / MGI
- respiratory distress / MGI
- premature death / MGI
- neurodegeneration / MGI
- muscular atrophy / MGI
- cryptorchism / MGI
- increased neuron apoptosis / MGI
- abnormal nervous system physiology / MGI
- spleen atrophy / MGI
- thymus atrophy / MGI
- abnormal uterine environment / MGI
- decreased skeletal muscle mass / MGI
- small epididymis / MGI
- abnormal B cell morphology / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased double-positive T cell number / MGI
- cachexia / MGI
- abnormal nerve conduction / MGI
- abnormal cell physiology / MGI
- abnormal mitochondrial physiology / MGI
- increased T cell apoptosis / MGI
- decreased skeletal muscle fiber diameter / MGI
MGI phenotypes (gene matching)
- kyphosis / MGI
- abnormal male reproductive system morphology / MGI
- small testis / MGI
- postnatal growth retardation / MGI
- respiratory distress / MGI
- premature death / MGI
- neurodegeneration / MGI
- muscular atrophy / MGI
- cryptorchism / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- abnormal nervous system physiology / MGI
- spleen atrophy / MGI
- thymus atrophy / MGI
- abnormal uterine environment / MGI
- decreased skeletal muscle mass / MGI
- small epididymis / MGI
- abnormal B cell morphology / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased double-positive T cell number / MGI
- cachexia / MGI
- abnormal nerve conduction / MGI
- abnormal cell physiology / MGI
- abnormal mitochondrial physiology / MGI
- increased T cell apoptosis / MGI
- decreased skeletal muscle fiber diameter / MGI
Literature references
- Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.;Cipolat Sara, Rudka Tomasz, Hartmann Dieter, Costa Veronica, Serneels Lutgarde, Craessaerts Katleen, Metzger Kristine, Frezza Christian, Annaert Wim, D'Adamio Luciano, Derks Carmen, Dejaegere Tim, Pellegrini Luca, D'Hooge Rudi, Scorrano Luca, De Strooper Bart, ;2006;Cell;126;163-75; 16839884