IMPC phenotypes (gene matching)
B6.129S7-Pof1btm1Toni/Cnrm
| Status | Available to order |
| EMMA ID | EM:02072 |
| International strain name | B6.129S7-Pof1btm1Toni/Cnrm |
| Alternative name | Pofib3b6/1h11 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pof1btm1Toni |
| Gene/Transgene symbol | Pof1b |
Information from provider
| Provider | Daniela Toniolo |
| Provider affiliation | San Raffaele Scientific Institute |
| Genetic information | Insertion of the lacZ-neo cassette in the StuI site of first exon of Pof1b gene, 192 bp from the ATG. |
| Phenotypic information | No defects could be detected. |
| Breeding history | Mice were backcrossed for 7 generations to C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
Literature references
- Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B.;Bione S, Rizzolio F, Sala C, Ricotti R, Goegan M, Manzini M C, Battaglia R, Marozzi A, Vegetti W, Dalprà L, Crosignani P G, Ginelli E, Nappi R, Bernabini S, Bruni V, Torricelli F, Zuffardi O, Toniolo D, ;2004;Human reproduction (Oxford, England);19;2759-66; 15459172
- Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure.;Lacombe Arnaud, Lee Hane, Zahed Laila, Choucair Mahmoud, Muller Jean-Marc, Nelson Stanley F, Salameh Wael, Vilain Eric, ;2006;American journal of human genetics;79;113-9; 16773570