B6.129-Trp53inp1tm1Acar/Orl

Status

Available to order

EMMA IDEM:02038
Citation informationRRID:IMSR_EM:02038 

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International strain nameB6.129-Trp53inp1tm1Acar/Orl
Alternative nameTP53INP1 KO B6
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTrp53inp1tm1Acar
Gene/Transgene symbolTrp53inp1

Information from provider

ProviderAlice Carrier
Provider affiliationInserm U624
Genetic informationA null mutation was introduced in 129/Sv ES cells by replacing coding exons 2, 3 and 4 of Trp53inp1 gene with a neomycin resistance cassette. This cassette contains the neo gene and the gene encoding the cre recombinase designed for self-excision in male germline, flanked by loxP sites (Bunting M et al., Genes&Dev. 1999, 13/1524; Genbank AF169416).
Phenotypic informationNone.
Breeding historyMutation was introduced in 129/Sv ES cells, chimeric males were mated to C57BL/6 females to generate heterozygous pups on mixed 129/Sv x C57BL/6 background, then backcrossed on C57BL/6 background for 8 generations. The strain is currently bred on B6 background.
References
  • Molecular and functional characterization of the stress-induced protein (SIP) gene and its two transcripts generated by alternative splicing. SIP induced by stress and promotes cell death.;Tomasini R, Samir A A, Vaccaro M I, Pebusque M J, Dagorn J C, Iovanna J L, Dusetti N J, ;2001;The Journal of biological chemistry;276;44185-92; 11557757
  • p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.;Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng C C, Taya Y, Monden M, Nakamura Y, ;2001;Molecular cell;8;85-94; 11511362
  • P53-dependent expression of the stress-induced protein (SIP).;Tomasini Richard, Samir Amina Azizi, Pebusque Marie-Josèphe, Calvo Ezequiel L, Totaro Serena, Dagorn Jean Charles, Dusetti Nelson J, Iovanna Juan L, ;2002;European journal of cell biology;81;294-301; 12067065
  • TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.;Tomasini Richard, Samir Amina Azizi, Carrier Alice, Isnardon Daniel, Cecchinelli Barbara, Soddu Silvia, Malissen Bernard, Dagorn Jean-Charles, Iovanna Juan L, Dusetti Nelson J, ;2003;The Journal of biological chemistry;278;37722-9; 12851404
  • Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer.;Jiang Pei-Hong, Motoo Yoshiharu, Garcia Stéphane, Iovanna Juan Lucio, Pébusque Marie-Josèphe, Sawabu Norio, ;2006;World journal of gastroenterology;12;691-6; 16521180
  • Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.;Gommeaux Julien, Cano Carla, Garcia Stéphane, Gironella Meritxell, Pietri Sylvia, Culcasi Marcel, Pébusque Marie-Josèphe, Malissen Bernard, Dusetti Nelson, Iovanna Juan, Carrier Alice, ;2007;Molecular and cellular biology;27;2215-28; 17242209

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • abnormal cell morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • increased body weight / MGI
  • hyperglycemia / MGI
  • neoplasm / MGI
  • increased colonic adenoma incidence / MGI
  • increased circulating insulin level / MGI
  • hepatic steatosis / MGI
  • increased liver weight / MGI
  • large intestinal inflammation / MGI
  • oxidative stress / MGI
  • increased incidence of tumors by chemical induction / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • increased susceptibility to weight gain / MGI
  • increased susceptibility to diet-induced obesity / MGI
  • abnormal mitochondrion morphology / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal epididymal fat pad morphology / MGI
  • increased susceptibility to induced colitis / MGI
  • abnormal renal fat pad morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal respiratory electron transport chain / MGI
  • abnormal oxidative phosphorylation / MGI
  • increased mitochondria number / MGI
  • abnormal mitophagy / MGI
  • increased body fat mass / MGI
  • increased susceptibility to diet-induced non-insulin dependent diabetes / MGI
MGI phenotypes (gene matching)
  • abnormal cell morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • increased body weight / MGI
  • hyperglycemia / MGI
  • neoplasm / MGI
  • increased colon adenoma incidence / MGI
  • increased circulating insulin level / MGI
  • hepatic steatosis / MGI
  • increased liver weight / MGI
  • large intestinal inflammation / MGI
  • oxidative stress / MGI
  • increased incidence of tumors by chemical induction / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • increased susceptibility to weight gain / MGI
  • increased susceptibility to diet-induced obesity / MGI
  • abnormal mitochondrion morphology / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal epididymal fat pad morphology / MGI
  • increased susceptibility to induced colitis / MGI
  • abnormal renal fat pad morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal respiratory electron transport chain / MGI
  • abnormal oxidative phosphorylation / MGI
  • increased mitochondria number / MGI
  • abnormal mitophagy / MGI
  • increased body fat mass / MGI
  • increased susceptibility to diet-induced non-insulin dependent diabetes / MGI

Literature references

  • Molecular and functional characterization of the stress-induced protein (SIP) gene and its two transcripts generated by alternative splicing. SIP induced by stress and promotes cell death.;Tomasini R, Samir A A, Vaccaro M I, Pebusque M J, Dagorn J C, Iovanna J L, Dusetti N J, ;2001;The Journal of biological chemistry;276;44185-92; 11557757
  • p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.;Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng C C, Taya Y, Monden M, Nakamura Y, ;2001;Molecular cell;8;85-94; 11511362
  • P53-dependent expression of the stress-induced protein (SIP).;Tomasini Richard, Samir Amina Azizi, Pebusque Marie-Josèphe, Calvo Ezequiel L, Totaro Serena, Dagorn Jean Charles, Dusetti Nelson J, Iovanna Juan L, ;2002;European journal of cell biology;81;294-301; 12067065
  • TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.;Tomasini Richard, Samir Amina Azizi, Carrier Alice, Isnardon Daniel, Cecchinelli Barbara, Soddu Silvia, Malissen Bernard, Dagorn Jean-Charles, Iovanna Juan L, Dusetti Nelson J, ;2003;The Journal of biological chemistry;278;37722-9; 12851404
  • Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer.;Jiang Pei-Hong, Motoo Yoshiharu, Garcia Stéphane, Iovanna Juan Lucio, Pébusque Marie-Josèphe, Sawabu Norio, ;2006;World journal of gastroenterology;12;691-6; 16521180
  • Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.;Gommeaux Julien, Cano Carla, Garcia Stéphane, Gironella Meritxell, Pietri Sylvia, Culcasi Marcel, Pébusque Marie-Josèphe, Malissen Bernard, Dusetti Nelson, Iovanna Juan, Carrier Alice, ;2007;Molecular and cellular biology;27;2215-28; 17242209

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