B6.Cg-Tg(Prnp/IGHG1)588Aag/Cnrm
| Status | Available to order |
| EMMA ID | EM:02031 |
| Citation information | RRID:IMSR_EM:02031 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Prnp/IGHG1)588Aag/Cnrm |
| Alternative name | PrPFcSTOP588 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp/IGHG1)588Aag |
| Gene/Transgene symbol | Tg(Prnp/IGHG1)588Aag |
Information from provider
| Provider | Adriano Aguzzi |
| Provider affiliation | Univ.Hosp.Zurich/Inst.Neuropathology |
| Genetic information | The pHGStopPrP-Fc construct was used for nuclear injection, with a loxP-flanked transcriptional stop cassette (pBS302, Invitrogen) inserted upstream of the PrP-Fc ORF. The generated Tg588 line can be bred with a cre recombinase-expressing line to enable ubiquitous or tissue-specific expression of PrP-Fc. |
| Phenotypic information | None. |
| Breeding history | A founder of the Tg588 line was bred with a C57BL/6 mouse. Breeding of transgene-hemizygous animals (with wild-type Prnp +/+ genotype) with C57BL/6 mice continued for more than 5 generations. The Tg588 transgene-positive mice are viable and without any defect also on the Prnp -/- (129/Sv x C57BL/6) background. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease.;Meier Philipp, Genoud Nicolas, Prinz Marco, Maissen Manuela, Rülicke Thomas, Zurbriggen Andreas, Raeber Alex J, Aguzzi Adriano, ;2003;Cell;113;49-60; 12679034