IMPC phenotypes (gene matching)
129-Trraptm1.1Zqw/Orl
| Status | Available to order |
| EMMA ID | EM:02013 |
| International strain name | 129-Trraptm1.1Zqw/Orl |
| Alternative name | Trrap+/delta |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trraptm1.1Zqw |
| Gene/Transgene symbol | Trrap |
Information from provider
| Provider | Zdenko Herceg |
| Provider affiliation | International Agency for Research on Cancer (IARC) |
| Genetic information | An exon was deleted via in vitro Cre mediated recombination of an upstream single loxP site and the 3' loxP site of a downstream floxed neo cassette. |
| Phenotypic information | Homozygous embryos die at peri-implantation stage. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal cornea morphology / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- increased mean corpuscular volume / MGI
- absent inner cell mass / MGI
- abnormal trophoblast layer morphology / MGI
- abnormal trophoblast giant cell morphology / MGI
- increased circulating magnesium level / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality before implantation, complete penetrance / MGI
Literature references
- Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.;Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, Jackson S, Wang Z Q, ;2001;Nature genetics;29;206-11; 11544477