- anophthalmia / IMPC
B6Rcc.Cg-Spp1tm1Rit ApcMin/Cnrm
Status | Available to order |
EMMA ID | EM:02002 |
International strain name | B6Rcc.Cg-Spp1tm1Rit ApcMin/Cnrm |
Alternative name | C57 BL/6RCC Min/+ OPN-/- |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | ApcMin, Spp1tm1Rit |
Gene/Transgene symbol | Apc, Spp1 |
Information from provider
Provider | Ursula Günthert |
Provider affiliation | Institut für Pathologie, University of Basel |
Genetic information | Ethylnitrosurea induced mutation. A transversion point mutation in the Apc (adenomatosis polyposis coli) gene that alters nucleotide 2549 from a T to an A and converts codon 850 from one encoding a leucine to a stop codon, generating the mutant allele ApcMin (adenomatosis polyposis coli; multiple intestinal neoplasia). The neomycin cassette from pMC1neo was inserted into the EagI site in exon 6 of the Spp1 (secreted phosphoprotein 1; formerly: Opn, osteopontin) gene (a 4.8 kb fragment from 129 mice), that had been cloned into pBluescript (Rittling et al., 1998). |
Phenotypic information | Min/+: development of early stages of colon carcinoma: polyps. Opn (Spp1) -/-: influence on colon carcinoma not known. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Desmoid tumor / Orphanet_873
- Cenani-Lenz syndrome / Orphanet_3258
- Turcot syndrome with polyposis / Orphanet_99818
- Gastric adenocarcinoma and proximal polyposis of the stomach / Orphanet_314022
- Gardner syndrome / Orphanet_79665
- APC-related attenuated familial adenomatous polyposis / Orphanet_247806
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- abnormal mammary gland development / MGI
- abnormal ovarian folliculogenesis / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina epithelium morphology / MGI
- decreased body weight / MGI
- increased incidence of induced tumors / MGI
- ovary atrophy / MGI
- uterus atrophy / MGI
- reproductive system phenotype / MGI
- adrenal gland hyperplasia / MGI
- absent nipple / MGI
- increased mammary gland tumor incidence / MGI
- mammary gland hyperplasia / MGI
- anemia / MGI
- premature death / MGI
- increased intestinal adenoma incidence / MGI
- increased intestinal adenocarcinoma incidence / MGI
- abnormal pregnancy / MGI
- extended life span / MGI
- aneuploidy / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased intestinal adenoma incidence / MGI
- decreased hematocrit / MGI
- hyperlipidemia / MGI
- melena / MGI
- rectal prolapse / MGI
- abnormal intestinal mucosa morphology / MGI
- increased mammary adenocarcinoma incidence / MGI
- intestinal obstruction / MGI
- abnormal intestinal goblet cell morphology / MGI
- abnormal large intestine crypts of Lieberkuhn morphology / MGI
- intestine polyps / MGI
- abnormal enterocyte proliferation / MGI
- decreased T cell number / MGI
- decreased NK cell number / MGI
- decreased splenocyte number / MGI
- neoplasm / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- postnatal growth retardation / MGI
- increased colonic adenoma incidence / MGI
- hepatic steatosis / MGI
- decreased macrophage cell number / MGI
- increased prostaglandin level / MGI
- abnormal embryo development / MGI
- abnormal embryo size / MGI
- abnormal egg cylinder morphology / MGI
- abnormal cell physiology / MGI
- embryonic lethality, complete penetrance / MGI
- decreased embryo size / MGI
- embryonic lethality between implantation and placentation / MGI
- absent mandible / MGI
- abnormal brain development / MGI
- acrania / MGI
- perinatal lethality, complete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- absent midbrain / MGI
- absent forebrain / MGI
- abnormal liver morphology / MGI
- decreased acute inflammation / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased bone mineral density / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal inflammatory response / MGI
- decreased susceptibility to viral infection / MGI
- dilated renal tubules / MGI
- decreased heart weight / MGI
- delayed wound healing / MGI
- nervous system phenotype / MGI
- abnormal physiological neovascularization / MGI
- renal tubular necrosis / MGI
- increased osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- decreased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- abnormal response to infection / MGI
- decreased cardiac muscle contractility / MGI
- increased susceptibility to injury / MGI
- skeleton phenotype / MGI
- hyporesponsive to tactile stimuli / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- increased interleukin-10 secretion / MGI
- decreased interleukin-12 secretion / MGI
- increased interleukin-4 secretion / MGI
- decreased sensitivity to induced cell death / MGI
- increased trabecular bone thickness / MGI
- mortality/aging / MGI
- decreased fibroblast chemotaxis / MGI
- increased bone marrow cell number / MGI
- abnormal blood cell morphology/development / MGI
- abnormal bone mineralization / MGI
- increased hematopoietic stem cell number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
MGI phenotypes (gene matching)
- absent mandible / MGI
- decreased hematocrit / MGI
- increased cell proliferation / MGI
- abnormal digestive system morphology / MGI
- gastrointestinal hemorrhage / MGI
- abnormal foregut morphology / MGI
- abnormal crypts of Lieberkuhn morphology / MGI
- rectal prolapse / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal mammary gland development / MGI
- mammary gland hyperplasia / MGI
- abnormal brain development / MGI
- abnormal floor plate morphology / MGI
- abnormal ovarian folliculogenesis / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina epithelium morphology / MGI
- dermal cysts / MGI
- decreased body weight / MGI
- decreased body size / MGI
- increased metastatic potential / MGI
- abnormal nursing / MGI
- hunched posture / MGI
- hyperlipidemia / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- anemia / MGI
- extended life span / MGI
- abnormal embryo development / MGI
- abnormal embryo size / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- postnatal growth retardation / MGI
- increased mammary adenocarcinoma incidence / MGI
- neoplasm / MGI
- increased pilomatricoma incidence / MGI
- increased tumor incidence / MGI
- increased incidence of induced tumors / MGI
- increased colon adenoma incidence / MGI
- premature death / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- increased intestinal adenoma incidence / MGI
- hepatic steatosis / MGI
- increased trichoepithelioma incidence / MGI
- increased intestinal adenocarcinoma incidence / MGI
- no phenotypic analysis / MGI
- abnormal egg cylinder morphology / MGI
- acrania / MGI
- colon polyps / MGI
- intestinal obstruction / MGI
- melena / MGI
- rectal hemorrhage / MGI
- gastric polyps / MGI
- increased hepatocellular carcinoma incidence / MGI
- epidermal cyst / MGI
- decreased tumor growth/size / MGI
- abnormal tumor morphology / MGI
- abnormal intestinal goblet cell morphology / MGI
- increased tumor growth/size / MGI
- increased osteosarcoma incidence / MGI
- decreased macrophage cell number / MGI
- abnormal embryonic epiblast morphology / MGI
- aneuploidy / MGI
- abnormal primitive node morphology / MGI
- cardia bifida / MGI
- increased incidence of tumors by chemical induction / MGI
- split notochord / MGI
- ovary atrophy / MGI
- abnormal large intestine crypts of Lieberkuhn morphology / MGI
- uterus atrophy / MGI
- decreased T cell number / MGI
- increased circulating cholesterol level / MGI
- cellular phenotype / MGI
- reproductive system phenotype / MGI
- abnormal cell physiology / MGI
- increased apoptosis / MGI
- abnormal hindbrain development / MGI
- absent male preputial gland / MGI
- intestine polyps / MGI
- increased liver tumor incidence / MGI
- decreased NK cell number / MGI
- abnormal anterior visceral endoderm morphology / MGI
- embryonic lethality / MGI
- abnormal enterocyte proliferation / MGI
- adrenal gland hyperplasia / MGI
- abnormal mesendoderm development / MGI
- increased small intestine adenocarcinoma incidence / MGI
- increased large intestine adenocarcinoma incidence / MGI
- decreased splenocyte number / MGI
- abnormal pregnancy / MGI
- absent nipple / MGI
- increased prostaglandin level / MGI
- embryonic lethality between implantation and placentation / MGI
- increased gastrointestinal tumor incidence / MGI
- increased mammary gland tumor incidence / MGI
- increased skin tumor incidence / MGI
- increased stomach tumor incidence / MGI
- increased osteoma incidence / MGI
- increased desmoid tumor incidence / MGI
- gastrointestinal tract polyps / MGI
- increased adenoma incidence / MGI
- altered tumor pathology / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- absent midbrain / MGI
- embryonic-extraembryonic boundary constriction / MGI
- absent forebrain / MGI
- rostral-caudal axis duplication / MGI
- rostral body truncation / MGI
- absent neural folds / MGI
- abnormal head development / MGI
- decreased intestinal adenoma incidence / MGI
- abnormal endocardial heart tube morphology / MGI
- increased bone mineral density / MGI
- abnormal long bone metaphysis morphology / MGI
- abnormal microglial cell morphology / MGI
- decreased hematocrit / MGI
- decreased leukocyte cell number / MGI
- abnormal blood flow velocity / MGI
- abnormal blood vessel physiology / MGI
- increased bone marrow cell number / MGI
- altered response to myocardial infarction / MGI
- abnormal liver morphology / MGI
- abnormal substantia nigra morphology / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal hematopoietic system physiology / MGI
- abnormal vasodilation / MGI
- abnormal blood vessel morphology / MGI
- abnormal immune system physiology / MGI
- altered susceptibility to infection / MGI
- abnormal inflammatory response / MGI
- decreased susceptibility to viral infection / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal blood cell morphology/development / MGI
- abnormal leukocyte physiology / MGI
- abnormal macrophage morphology / MGI
- abnormal macrophage physiology / MGI
- granulomatous inflammation / MGI
- increased heart rate / MGI
- decreased circulating triglyceride level / MGI
- dilated renal tubules / MGI
- decreased circulating insulin level / MGI
- decreased heart weight / MGI
- decreased systemic arterial blood pressure / MGI
- decreased hemoglobin content / MGI
- increased insulin sensitivity / MGI
- abnormal bone mineralization / MGI
- delayed wound healing / MGI
- abnormal leukocyte migration / MGI
- nephrocalcinosis / MGI
- nervous system phenotype / MGI
- abnormal physiological neovascularization / MGI
- impaired macrophage chemotaxis / MGI
- decreased macrophage cell number / MGI
- decreased lean body mass / MGI
- abnormal striatum morphology / MGI
- renal tubular necrosis / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased hematopoietic stem cell number / MGI
- decreased susceptibility to experimental autoimmune uveoretinitis / MGI
- lung cysts / MGI
- abnormal vascular wound healing / MGI
- increased osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- decreased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- increased lymphocyte cell number / MGI
- abnormal wound healing / MGI
- abnormal response to infection / MGI
- decreased acute inflammation / MGI
- decreased cardiac muscle contractility / MGI
- increased susceptibility to injury / MGI
- improved glucose tolerance / MGI
- decreased susceptibility to atherosclerosis / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- increased macrophage cell number / MGI
- hyporesponsive to tactile stimuli / MGI
- increased circulating creatinine level / MGI
- decreased circulating glucose level / MGI
- increased blood urea nitrogen level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- increased lung weight / MGI
- calcified aortic valve / MGI
- decreased systemic arterial systolic blood pressure / MGI
- decreased urine sodium level / MGI
- decreased dendritic cell number / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-6 level / MGI
- increased interleukin-10 secretion / MGI
- decreased interleukin-12 secretion / MGI
- increased interleukin-4 secretion / MGI
- abnormal chemokine level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased sensitivity to induced cell death / MGI
- increased neuron number / MGI
- increased trabecular bone thickness / MGI
- crystalluria / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased respiratory quotient / MGI
- abnormal macrophage chemotaxis / MGI
- mortality/aging / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
- decreased urine chloride ion level / MGI
- decreased fibroblast chemotaxis / MGI
Literature references
- A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722
- Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro.;Rittling S R, Matsumoto H N, McKee M D, Nanci A, An X R, Novick K E, Kowalski A J, Noda M, Denhardt D T, ;1998;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;13;1101-11; 9661074
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