B6Rcc.B6J-Apc^Min/Cnrm

Status	Available to order
EMMA ID	EM:02000
International strain name	B6Rcc.B6J-Apc^Min/Cnrm
Alternative name	C57 BL/6RCC Min/+
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Apc^Min
Gene/Transgene symbol	Apc

Information from provider

Provider	Ursula Günthert
Provider affiliation	Institut für Pathologie, University of Basel
Genetic information	Ethylnitrosurea induced mutation. A transversion point mutation in the Apc (adenomatosis polyposis coli) gene that alters nucleotide 2549 from a T to an A and converts codon 850 from leucine-encoding to a stop, generating the mutant allele Apc^Min (adenomatosis polyposis coli; multiple intestinal neoplasia).
Phenotypic information	Min/+: development of early stages of colon carcinoma, polyps.
Breeding history	10 generations backcrossed onto C57BL/6Rcc.
References	A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

Desmoid tumor / Orphanet_873
Cenani-Lenz syndrome / Orphanet_3258
Turcot syndrome with polyposis / Orphanet_99818
Gastric adenocarcinoma and proximal polyposis of the stomach / Orphanet_314022
Gardner syndrome / Orphanet_79665
APC-related attenuated familial adenomatous polyposis / Orphanet_247806

MGI phenotypes (allele matching)

abnormal mammary gland development / MGI
abnormal ovarian folliculogenesis / MGI
abnormal ovarian follicle morphology / MGI
absent mature ovarian follicles / MGI
absent corpus luteum / MGI
abnormal vagina epithelium morphology / MGI
decreased body weight / MGI
increased incidence of induced tumors / MGI
ovary atrophy / MGI
uterus atrophy / MGI
reproductive system phenotype / MGI
adrenal gland hyperplasia / MGI
absent nipple / MGI
increased mammary gland tumor incidence / MGI
mammary gland hyperplasia / MGI
anemia / MGI
premature death / MGI
increased intestinal adenoma incidence / MGI
increased intestinal adenocarcinoma incidence / MGI
abnormal pregnancy / MGI
extended life span / MGI
aneuploidy / MGI
increased incidence of tumors by chemical induction / MGI
decreased intestinal adenoma incidence / MGI
decreased hematocrit / MGI
hyperlipidemia / MGI
melena / MGI
rectal prolapse / MGI
abnormal intestinal mucosa morphology / MGI
increased mammary adenocarcinoma incidence / MGI
intestinal obstruction / MGI
abnormal intestinal goblet cell morphology / MGI
abnormal large intestine crypts of Lieberkuhn morphology / MGI
intestine polyps / MGI
abnormal enterocyte proliferation / MGI
decreased T cell number / MGI
decreased NK cell number / MGI
decreased splenocyte number / MGI
neoplasm / MGI
increased circulating triglyceride level / MGI
increased circulating free fatty acid level / MGI
postnatal growth retardation / MGI
increased colonic adenoma incidence / MGI
hepatic steatosis / MGI
decreased macrophage cell number / MGI
increased prostaglandin level / MGI
abnormal embryo development / MGI
abnormal embryo size / MGI
abnormal egg cylinder morphology / MGI
abnormal cell physiology / MGI
embryonic lethality, complete penetrance / MGI
decreased embryo size / MGI
embryonic lethality between implantation and placentation / MGI
absent mandible / MGI
abnormal brain development / MGI
acrania / MGI
perinatal lethality, complete penetrance / MGI
lethality throughout fetal growth and development, incomplete penetrance / MGI
absent midbrain / MGI
absent forebrain / MGI

MGI phenotypes (gene matching)

absent mandible / MGI
decreased hematocrit / MGI
increased cell proliferation / MGI
abnormal digestive system morphology / MGI
gastrointestinal hemorrhage / MGI
abnormal foregut morphology / MGI
abnormal crypts of Lieberkuhn morphology / MGI
rectal prolapse / MGI
abnormal intestinal mucosa morphology / MGI
abnormal mammary gland development / MGI
mammary gland hyperplasia / MGI
abnormal brain development / MGI
abnormal floor plate morphology / MGI
abnormal ovarian folliculogenesis / MGI
abnormal ovarian follicle morphology / MGI
absent mature ovarian follicles / MGI
absent corpus luteum / MGI
abnormal vagina epithelium morphology / MGI
dermal cysts / MGI
decreased body weight / MGI
decreased body size / MGI
increased metastatic potential / MGI
abnormal nursing / MGI
hunched posture / MGI
hyperlipidemia / MGI
increased circulating triglyceride level / MGI
increased circulating free fatty acid level / MGI
anemia / MGI
extended life span / MGI
abnormal embryo development / MGI
abnormal embryo size / MGI
decreased embryo size / MGI
incomplete embryo turning / MGI
postnatal growth retardation / MGI
increased mammary adenocarcinoma incidence / MGI
neoplasm / MGI
increased pilomatricoma incidence / MGI
increased tumor incidence / MGI
increased incidence of induced tumors / MGI
increased colon adenoma incidence / MGI
premature death / MGI
abnormal developmental patterning / MGI
abnormal embryonic tissue morphology / MGI
abnormal neural tube morphology / MGI
no abnormal phenotype detected / MGI
increased intestinal adenoma incidence / MGI
hepatic steatosis / MGI
increased trichoepithelioma incidence / MGI
increased intestinal adenocarcinoma incidence / MGI
no phenotypic analysis / MGI
abnormal egg cylinder morphology / MGI
acrania / MGI
colon polyps / MGI
intestinal obstruction / MGI
melena / MGI
rectal hemorrhage / MGI
gastric polyps / MGI
increased hepatocellular carcinoma incidence / MGI
epidermal cyst / MGI
decreased tumor growth/size / MGI
abnormal tumor morphology / MGI
abnormal intestinal goblet cell morphology / MGI
increased tumor growth/size / MGI
increased osteosarcoma incidence / MGI
decreased macrophage cell number / MGI
abnormal embryonic epiblast morphology / MGI
aneuploidy / MGI
abnormal primitive node morphology / MGI
cardia bifida / MGI
increased incidence of tumors by chemical induction / MGI
split notochord / MGI
ovary atrophy / MGI
abnormal large intestine crypts of Lieberkuhn morphology / MGI
uterus atrophy / MGI
decreased T cell number / MGI
increased circulating cholesterol level / MGI
cellular phenotype / MGI
reproductive system phenotype / MGI
abnormal cell physiology / MGI
increased apoptosis / MGI
abnormal hindbrain development / MGI
absent male preputial gland / MGI
intestine polyps / MGI
increased liver tumor incidence / MGI
decreased NK cell number / MGI
abnormal anterior visceral endoderm morphology / MGI
embryonic lethality / MGI
abnormal enterocyte proliferation / MGI
adrenal gland hyperplasia / MGI
abnormal mesendoderm development / MGI
increased small intestine adenocarcinoma incidence / MGI
increased large intestine adenocarcinoma incidence / MGI
decreased splenocyte number / MGI
abnormal pregnancy / MGI
absent nipple / MGI
increased prostaglandin level / MGI
embryonic lethality between implantation and placentation / MGI
increased gastrointestinal tumor incidence / MGI
increased mammary gland tumor incidence / MGI
increased skin tumor incidence / MGI
increased stomach tumor incidence / MGI
increased osteoma incidence / MGI
increased desmoid tumor incidence / MGI
gastrointestinal tract polyps / MGI
increased adenoma incidence / MGI
altered tumor pathology / MGI
mortality/aging / MGI
postnatal lethality, complete penetrance / MGI
postnatal lethality, incomplete penetrance / MGI
perinatal lethality, complete penetrance / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality, complete penetrance / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
lethality throughout fetal growth and development, incomplete penetrance / MGI
absent midbrain / MGI
embryonic-extraembryonic boundary constriction / MGI
absent forebrain / MGI
rostral-caudal axis duplication / MGI
rostral body truncation / MGI
absent neural folds / MGI
abnormal head development / MGI
decreased intestinal adenoma incidence / MGI
abnormal endocardial heart tube morphology / MGI

Literature references

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722
Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer.;Wei Tzu-Tang, Lin Yi-Ting, Chen Wen-Shu, Luo Ping, Lin Yu-Chin, Shun Chia-Tung, Lin Yi-Hsin, Chen Jhih-Bin, Chen Nai-Wei, Fang Jim-Min, Wu Ming-Shiang, Yang Kai-Chien, Chang Li-Chun, Tai Kang-Yu, Liang Jin-Tung, Chen Ching-Chow, ;2016;EBioMedicine;10;124-36; 27448759

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

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B6Rcc.B6J-ApcMin/Cnrm