IMPC phenotypes (gene matching)
- anophthalmia / IMPC
B6Rcc.129S7-Spp1tm1Rit/Cnrm
| Status | Available to order |
| EMMA ID | EM:01993 |
| Citation information | RRID:IMSR_EM:01993 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6Rcc.129S7-Spp1tm1Rit/Cnrm |
| Alternative name | C57 BL/6RCC OPN-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Spp1tm1Rit |
| Gene/Transgene symbol | Spp1 |
Information from provider
| Provider | Ursula Günthert |
| Provider affiliation | Institut für Pathologie, University of Basel |
| Genetic information | The neomycin cassette from pMC1neo was inserted into the EagI site in exon 6 of the Spp1 (secreted phosphoprotein 1; formerly: Opn, osteopontin) gene (a 4.8 kb fragment from 129 mice), that had been cloned into pBluescript (Rittling et al., 1998). |
| Phenotypic information | Strongly reduced symptoms in autoimmune diseases and impaired bone remodeling. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
- abnormal liver morphology / MGI
- decreased acute inflammation / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased bone mineral density / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal inflammatory response / MGI
- decreased susceptibility to viral infection / MGI
- dilated renal tubules / MGI
- decreased heart weight / MGI
- delayed wound healing / MGI
- nervous system phenotype / MGI
- abnormal physiological neovascularization / MGI
- renal tubular necrosis / MGI
- increased osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- decreased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- abnormal response to infection / MGI
- decreased cardiac muscle contractility / MGI
- increased susceptibility to injury / MGI
- skeleton phenotype / MGI
- hyporesponsive to tactile stimuli / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- increased interleukin-10 secretion / MGI
- decreased interleukin-12 secretion / MGI
- increased interleukin-4 secretion / MGI
- decreased sensitivity to induced cell death / MGI
- increased trabecular bone thickness / MGI
- mortality/aging / MGI
- decreased fibroblast chemotaxis / MGI
- increased bone marrow cell number / MGI
- abnormal blood cell morphology/development / MGI
- abnormal bone mineralization / MGI
- increased hematopoietic stem cell number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal long bone metaphysis morphology / MGI
- abnormal microglial cell morphology / MGI
- decreased hematocrit / MGI
- decreased leukocyte cell number / MGI
- abnormal blood flow velocity / MGI
- abnormal blood vessel physiology / MGI
- increased bone marrow cell number / MGI
- altered response to myocardial infarction / MGI
- abnormal liver morphology / MGI
- abnormal substantia nigra morphology / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal hematopoietic system physiology / MGI
- abnormal vasodilation / MGI
- abnormal blood vessel morphology / MGI
- abnormal immune system physiology / MGI
- altered susceptibility to infection / MGI
- abnormal inflammatory response / MGI
- decreased susceptibility to viral infection / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal blood cell morphology/development / MGI
- abnormal leukocyte physiology / MGI
- abnormal macrophage morphology / MGI
- abnormal macrophage physiology / MGI
- granulomatous inflammation / MGI
- increased heart rate / MGI
- decreased circulating triglyceride level / MGI
- dilated renal tubules / MGI
- decreased circulating insulin level / MGI
- decreased heart weight / MGI
- decreased systemic arterial blood pressure / MGI
- decreased hemoglobin content / MGI
- increased insulin sensitivity / MGI
- abnormal bone mineralization / MGI
- delayed wound healing / MGI
- abnormal leukocyte migration / MGI
- nephrocalcinosis / MGI
- nervous system phenotype / MGI
- abnormal physiological neovascularization / MGI
- impaired macrophage chemotaxis / MGI
- decreased macrophage cell number / MGI
- decreased lean body mass / MGI
- abnormal striatum morphology / MGI
- renal tubular necrosis / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased hematopoietic stem cell number / MGI
- decreased susceptibility to experimental autoimmune uveoretinitis / MGI
- lung cysts / MGI
- abnormal vascular wound healing / MGI
- increased osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- decreased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- increased lymphocyte cell number / MGI
- abnormal wound healing / MGI
- abnormal response to infection / MGI
- decreased acute inflammation / MGI
- decreased cardiac muscle contractility / MGI
- increased susceptibility to injury / MGI
- improved glucose tolerance / MGI
- decreased susceptibility to atherosclerosis / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- increased macrophage cell number / MGI
- hyporesponsive to tactile stimuli / MGI
- increased circulating creatinine level / MGI
- decreased circulating glucose level / MGI
- increased blood urea nitrogen level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- increased lung weight / MGI
- calcified aortic valve / MGI
- decreased systemic arterial systolic blood pressure / MGI
- decreased urine sodium level / MGI
- decreased dendritic cell number / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-6 level / MGI
- increased interleukin-10 secretion / MGI
- decreased interleukin-12 secretion / MGI
- increased interleukin-4 secretion / MGI
- abnormal chemokine level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased sensitivity to induced cell death / MGI
- increased neuron number / MGI
- increased trabecular bone thickness / MGI
- crystalluria / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased respiratory quotient / MGI
- abnormal macrophage chemotaxis / MGI
- mortality/aging / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
- decreased urine chloride ion level / MGI
- decreased fibroblast chemotaxis / MGI
Literature references
- The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.;Chabas D, Baranzini S E, Mitchell D, Bernard C C, Rittling S R, Denhardt D T, Sobel R A, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg J R, Steinman L, ;2001;Science (New York, N.Y.);294;1731-5; 11721059
- Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro.;Rittling S R, Matsumoto H N, McKee M D, Nanci A, An X R, Novick K E, Kowalski A J, Noda M, Denhardt D T, ;1998;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;13;1101-11; 9661074
- Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival.;Denhardt D T, Noda M, O'Regan A W, Pavlin D, Berman J S, ;2001;The Journal of clinical investigation;107;1055-61; 11342566