IMPC phenotypes (gene matching)
129-M6prtm1Psa/Cnrm
| Status | Available to order |
| EMMA ID | EM:01985 |
| Citation information | RRID:IMSR_EM:01985 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-M6prtm1Psa/Cnrm |
| Alternative name | mpr46 -/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | M6prtm1Psa |
| Gene/Transgene symbol | M6pr |
Information from provider
| Provider | Regina Pohlmann |
| Provider affiliation | UKM (University Klinikum Muenster) |
| Genetic information | Targeted disruption of M6pr (MPR46) gene by insertion of a neomycin selection cassette in exon 3. See EMBO J. 12, 5219-5223 (1993) and Eur J Biochem. 224(2), 685-689 (1994). |
| Phenotypic information | Missorting of lysosomal enzymes that appear to be recaptured by the second mammalian mannose 6-phosphate receptor (MPR300, Mr ca. 300000). |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.;Köster A, Saftig P, Matzner U, von Figura K, Peters C, Pohlmann R, ;1993;The EMBO journal;12;5219-23; 8262064
- Mistargeting of lysosomal enzymes in M(r) 46,000 mannose 6-phosphate receptor-deficient mice is compensated by carbohydrate-specific endocytotic receptors.;Köster A, von Figura K, Pohlmann R, ;1994;European journal of biochemistry;224;685-9; 7925385