129-M6prtm1Psa/Cnrm
Status | Available to order |
EMMA ID | EM:01985 |
International strain name | 129-M6prtm1Psa/Cnrm |
Alternative name | mpr46 -/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | M6prtm1Psa |
Gene/Transgene symbol | M6pr |
Information from provider
Provider | Regina Pohlmann |
Provider affiliation | UKM (University Klinikum Muenster) |
Genetic information | Targeted disruption of M6pr (MPR46) gene by insertion of a neomycin selection cassette in exon 3. See EMBO J. 12, 5219-5223 (1993) and Eur J Biochem. 224(2), 685-689 (1994). |
Phenotypic information | Missorting of lysosomal enzymes that appear to be recaptured by the second mammalian mannose 6-phosphate receptor (MPR300, Mr ca. 300000). |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
Literature references
- Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.;Köster A, Saftig P, Matzner U, von Figura K, Peters C, Pohlmann R, ;1993;The EMBO journal;12;5219-23; 8262064
- Mistargeting of lysosomal enzymes in M(r) 46,000 mannose 6-phosphate receptor-deficient mice is compensated by carbohydrate-specific endocytotic receptors.;Köster A, von Figura K, Pohlmann R, ;1994;European journal of biochemistry;224;685-9; 7925385
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