MGI phenotypes (allele matching)
B6;129P2-Polltm1Crey/Orl
| Status | Available to order |
| EMMA ID | EM:01973 |
| Citation information | RRID:IMSR_EM:01973 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Polltm1Crey/Orl |
| Alternative name | DNA polymerase lambda knockout |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Polltm1Crey |
| Gene/Transgene symbol | Poll |
Information from provider
| Provider | Barbara Bertocci |
| Provider affiliation | INSERM 783 ex373 |
| Genetic information | The region of lambda DNA polymerase gene (Poll) between exons 5 and 7 was deleted and replaced by the neomycin, which is flanked by two loxP sites. |
| Phenotypic information | Altered immunoglobulin heavy chain rearrangement. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous males, wild-type females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.;Bertocci Barbara, De Smet Annie, Flatter Eric, Dahan Auriel, Bories Jean-Christophe, Landreau Catherine, Weill Jean-Claude, Reynaud Claude-Agnès, ;2002;Journal of immunology (Baltimore, Md. : 1950);168;3702-6; 11937519