MGI phenotypes (allele matching)
B6;129P2-Polmtm1Crey/Orl
| Status | Available to order |
| EMMA ID | EM:01972 |
| Citation information | RRID:IMSR_EM:01972 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Polmtm1Crey/Orl |
| Alternative name | DNA polymerase mu knockouts |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Polmtm1Crey |
| Gene/Transgene symbol | Polm |
Information from provider
| Provider | Barbara Bertocci |
| Provider affiliation | INSERM 783 ex373 |
| Genetic information | The region of mu DNA polymerase gene (Polm) between exons 6 and 10 was deleted and replaced by neomycin, which is flanked by two loxP sites. |
| Phenotypic information | Peripheral B cell deficiency, impaired production of bone marrow, immature B cells and defects in immunoglobulin light chain rearrangement. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.;Bertocci Barbara, De Smet Annie, Flatter Eric, Dahan Auriel, Bories Jean-Christophe, Landreau Catherine, Weill Jean-Claude, Reynaud Claude-Agnès, ;2002;Journal of immunology (Baltimore, Md. : 1950);168;3702-6; 11937519
- Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu.;Bertocci Barbara, De Smet Annie, Berek Claudia, Weill Jean-Claude, Reynaud Claude-Agnès, ;2003;Immunity;19;203-11; 12932354