MGI phenotypes (allele matching)
B6;129P2-Polmtm1Crey/Orl
| Status | Available to order |
| EMMA ID | EM:01972 |
| International strain name | B6;129P2-Polmtm1Crey/Orl |
| Alternative name | DNA polymerase mu knockouts |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Polmtm1Crey |
| Gene/Transgene symbol | Polm |
Information from provider
| Provider | Barbara Bertocci |
| Provider affiliation | INSERM 783 ex373 |
| Genetic information | The region of mu DNA polymerase gene (Polm) between exons 6 and 10 was deleted and replaced by neomycin, which is flanked by two loxP sites. |
| Phenotypic information | Peripheral B cell deficiency, impaired production of bone marrow, immature B cells and defects in immunoglobulin light chain rearrangement. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.;Bertocci Barbara, De Smet Annie, Flatter Eric, Dahan Auriel, Bories Jean-Christophe, Landreau Catherine, Weill Jean-Claude, Reynaud Claude-Agnès, ;2002;Journal of immunology (Baltimore, Md. : 1950);168;3702-6; 11937519
- Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu.;Bertocci Barbara, De Smet Annie, Berek Claudia, Weill Jean-Claude, Reynaud Claude-Agnès, ;2003;Immunity;19;203-11; 12932354