STOCK Cdk5rap2an/Ieg

Status

Available to order

EMMA IDEM:00197
International strain nameSTOCK Cdk5rap2an/Ieg
Alternative nameHertwig`s anemia, an
Strain typeInduced Mutant Strains : Radiation-induced
Allele/Transgene symbolCdk5rap2an
Gene/Transgene symbolCdk5rap2

Information from provider

ProviderDietmar Schlote
Provider affiliationMartin-Luther University, Halle/Wittenberg
Phenotypic informationNormochromic macrocytic type of anemia, lethal within the first post-natal weeks.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased body weight / IMPC
  • decreased lean body mass / IMPC
  • increased mean corpuscular volume / IMPC
  • abnormal head morphology / IMPC
  • hyperplasia / IMPC
  • hypoplasia / IMPC
  • decreased bone mineral content / IMPC
  • extramedullary hemopoiesis / IMPC
  • decreased leukocyte cell number / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • abnormal cranium morphology / IMPC
MGI phenotypes (allele matching)
  • microcephaly / MGI
  • decreased brain size / MGI
  • abnormal cerebral cortex morphology / MGI
  • decreased body size / MGI
  • premature death / MGI
  • small olfactory bulb / MGI
  • increased neuron apoptosis / MGI
  • abnormal forebrain development / MGI
  • loss of cortex neurons / MGI
  • abnormal mitosis / MGI
  • abnormal embryonic/fetal subventricular zone morphology / MGI
  • thin cerebral cortex / MGI
  • small hippocampus / MGI
  • abnormal mitotic spindle morphology / MGI
  • abnormal neuron proliferation / MGI
  • enlarged brain ventricles / MGI
  • kyphosis / MGI
  • decreased leukocyte cell number / MGI
  • abnormal erythropoiesis / MGI
  • macrocytosis / MGI
  • abnormal spermatogenesis / MGI
  • anemia / MGI
  • reduced fertility / MGI
  • postnatal lethality / MGI
  • decreased germ cell number / MGI
  • abnormal erythrocyte morphology / MGI
  • anisocytosis / MGI
  • macrocytic anemia / MGI
  • premature hair loss / MGI
  • decreased oocyte number / MGI
  • reticulocytopenia / MGI
  • eye opacity / MGI
  • increased ovary adenoma incidence / MGI
  • decreased erythrocyte cell number / MGI
MGI phenotypes (gene matching)
  • kyphosis / MGI
  • decreased leukocyte cell number / MGI
  • abnormal erythropoiesis / MGI
  • macrocytosis / MGI
  • abnormal head morphology / MGI
  • microcephaly / MGI
  • abnormal cranium morphology / MGI
  • decreased brain size / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • anemia / MGI
  • reduced fertility / MGI
  • male infertility / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • decreased germ cell number / MGI
  • abnormal erythrocyte morphology / MGI
  • increased mean corpuscular volume / MGI
  • anisocytosis / MGI
  • small olfactory bulb / MGI
  • macrocytic anemia / MGI
  • decreased erythrocyte cell number / MGI
  • abnormal cell nucleus morphology / MGI
  • increased neuron apoptosis / MGI
  • abnormal forebrain development / MGI
  • loss of cortex neurons / MGI
  • abnormal plasma membrane morphology / MGI
  • decreased lean body mass / MGI
  • abnormal mitosis / MGI
  • abnormal embryonic/fetal subventricular zone morphology / MGI
  • premature hair loss / MGI
  • cellular phenotype / MGI
  • decreased oocyte number / MGI
  • increased mean corpuscular hemoglobin / MGI
  • thin cerebral cortex / MGI
  • early cellular replicative senescence / MGI
  • small hippocampus / MGI
  • reticulocytopenia / MGI
  • abnormal mitotic spindle morphology / MGI
  • eye opacity / MGI
  • abnormal neuron proliferation / MGI
  • decreased bone mineral content / MGI
  • enlarged brain ventricles / MGI
  • increased ovary adenoma incidence / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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