STOCK Cdk5rap2^an/Ieg

Status	Available to order
EMMA ID	EM:00197
Citation information	RRID:IMSR_EM:00197 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	STOCK Cdk5rap2^an/Ieg
Alternative name	Hertwig`s anemia, an
Strain type	Induced Mutant Strains : Radiation-induced
Allele/Transgene symbol	Cdk5rap2^an
Gene/Transgene symbol	Cdk5rap2

Information from provider

Provider	Dietmar Schlote
Provider affiliation	Martin-Luther University, Halle/Wittenberg
Phenotypic information	Normochromic macrocytic type of anemia, lethal within the first post-natal weeks.
References	None available

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

microcephaly / DOID:10907

Orphanet associated rare diseases, based on orthologous gene matching

Autosomal recessive primary microcephaly / Orphanet_2512

IMPC phenotypes (gene matching)

decreased body weight / IMPC
decreased lean body mass / IMPC
increased mean corpuscular volume / IMPC
abnormal head morphology / IMPC
hyperplasia / IMPC
hypoplasia / IMPC
decreased bone mineral content / IMPC
extramedullary hemopoiesis / IMPC
decreased leukocyte cell number / IMPC
decreased erythrocyte cell number / IMPC
increased mean corpuscular hemoglobin / IMPC
abnormal cranium morphology / IMPC

MGI phenotypes (allele matching)

microcephaly / MGI
decreased brain size / MGI
abnormal cerebral cortex morphology / MGI
decreased body size / MGI
premature death / MGI
small olfactory bulb / MGI
increased neuron apoptosis / MGI
abnormal forebrain development / MGI
loss of cortex neurons / MGI
abnormal mitosis / MGI
abnormal embryonic/fetal subventricular zone morphology / MGI
thin cerebral cortex / MGI
small hippocampus / MGI
abnormal mitotic spindle morphology / MGI
abnormal neuron proliferation / MGI
enlarged brain ventricles / MGI
kyphosis / MGI
decreased leukocyte cell number / MGI
abnormal erythropoiesis / MGI
macrocytosis / MGI
abnormal spermatogenesis / MGI
anemia / MGI
reduced fertility / MGI
postnatal lethality / MGI
decreased germ cell number / MGI
abnormal erythrocyte morphology / MGI
anisocytosis / MGI
macrocytic anemia / MGI
premature hair loss / MGI
decreased oocyte number / MGI
reticulocytopenia / MGI
eye opacity / MGI
increased ovary adenoma incidence / MGI
decreased erythrocyte cell number / MGI

MGI phenotypes (gene matching)

kyphosis / MGI
decreased leukocyte cell number / MGI
abnormal erythropoiesis / MGI
macrocytosis / MGI
abnormal head morphology / MGI
microcephaly / MGI
abnormal cranium morphology / MGI
decreased brain size / MGI
abnormal cerebral cortex morphology / MGI
abnormal spermatogenesis / MGI
decreased body weight / MGI
decreased body size / MGI
anemia / MGI
reduced fertility / MGI
male infertility / MGI
postnatal lethality / MGI
premature death / MGI
decreased germ cell number / MGI
abnormal erythrocyte morphology / MGI
increased mean corpuscular volume / MGI
anisocytosis / MGI
small olfactory bulb / MGI
macrocytic anemia / MGI
decreased erythrocyte cell number / MGI
abnormal cell nucleus morphology / MGI
increased neuron apoptosis / MGI
abnormal forebrain development / MGI
loss of cortex neurons / MGI
abnormal plasma membrane morphology / MGI
decreased lean body mass / MGI
abnormal mitosis / MGI
abnormal embryonic/fetal subventricular zone morphology / MGI
premature hair loss / MGI
cellular phenotype / MGI
decreased oocyte number / MGI
increased mean corpuscular hemoglobin / MGI
thin cerebral cortex / MGI
early cellular replicative senescence / MGI
small hippocampus / MGI
reticulocytopenia / MGI
abnormal mitotic spindle morphology / MGI
eye opacity / MGI
abnormal neuron proliferation / MGI
decreased bone mineral content / MGI
enlarged brain ventricles / MGI
increased ovary adenoma incidence / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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