B6.Cg-Foxp3tm1.1Mal/Orl

Status

Available to order

EMMA IDEM:01945
Citation informationRRID:IMSR_EM:01945 

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International strain nameB6.Cg-Foxp3tm1.1Mal/Orl
Alternative nameB6-FoxP3tm1mal, FoxP3 EGFP
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolFoxp3.1tm1Mal
Gene/Transgene symbolFoxp3

Information from provider

ProviderBernard Malissen
Provider affiliationCentre D
Genetic informationAn IRES-EGFP cassette was introduced in the 3'-UTR region of Foxp3 gene, exon11. The autodeleter neomycin-cre recombinase cassette was used.
Phenotypic informationEGFP labels all regulatory T cells. Very specific labeling, all EGFP+ cells are FOXP3+.
References
  • Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.;Wang Ying, Kissenpfennig Adrien, Mingueneau Michael, Richelme Sylvie, Perrin Pierre, Chevrier Stéphane, Genton Céline, Lucas Bruno, DiSanto James P, Acha-Orbea Hans, Malissen Bernard, Malissen Marie, ;2008;Journal of immunology (Baltimore, Md. : 1950);180;1565-75; 18209052

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome / Orphanet_37042
MGI phenotypes (gene matching)
  • enlarged spleen / MGI
  • abnormal Peyer's patch morphology / MGI
  • decreased thymocyte number / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • weight loss / MGI
  • thymus hypoplasia / MGI
  • conjunctivitis / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal gut-associated lymphoid tissue morphology / MGI
  • no phenotypic analysis / MGI
  • lymph node inflammation / MGI
  • abnormal regulatory T cell morphology / MGI
  • increased regulatory T cell number / MGI
  • decreased regulatory T cell number / MGI
  • increased T cell number / MGI
  • decreased T cell number / MGI
  • decreased double-positive T cell number / MGI
  • cachexia / MGI
  • bradykinesia / MGI
  • abnormal mesenteric lymph node morphology / MGI
  • increased susceptibility to autoimmune disorder / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • increased T cell apoptosis / MGI
  • increased dendritic cell number / MGI
  • abnormal intraepithelial T cell morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • mortality/aging / MGI

Literature references

  • Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.;Wang Ying, Kissenpfennig Adrien, Mingueneau Michael, Richelme Sylvie, Perrin Pierre, Chevrier Stéphane, Genton Céline, Lucas Bruno, DiSanto James P, Acha-Orbea Hans, Malissen Bernard, Malissen Marie, ;2008;Journal of immunology (Baltimore, Md. : 1950);180;1565-75; 18209052
  • Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells.;Lalfer Mélanie, Chappert Pascal, Carpentier Maxime, Urbain Dominique, Davoust Jean M, Gross David-Alexandre, ;2019;Frontiers in immunology;10;521; 30941146

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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