B6.Cg-Foxp3tm1.1Mal/Orl

Status

Available to order

EMMA IDEM:01945
International strain nameB6.Cg-Foxp3tm1.1Mal/Orl
Alternative nameB6-FoxP3tm1mal, FoxP3 EGFP
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolFoxp3.1tm1Mal
Gene/Transgene symbolFoxp3

Information from provider

ProviderBernard Malissen
Provider affiliationCentre D
Genetic informationAn IRES-EGFP cassette was introduced in the 3'-UTR region of Foxp3 gene, exon11. The autodeleter neomycin-cre recombinase cassette was used.
Phenotypic informationEGFP labels all regulatory T cells. Very specific labeling, all EGFP+ cells are FOXP3+.
References
  • Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.;Wang Ying, Kissenpfennig Adrien, Mingueneau Michael, Richelme Sylvie, Perrin Pierre, Chevrier Stéphane, Genton Céline, Lucas Bruno, DiSanto James P, Acha-Orbea Hans, Malissen Bernard, Malissen Marie, ;2008;Journal of immunology (Baltimore, Md. : 1950);180;1565-75; 18209052

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome / Orphanet_37042
MGI phenotypes (gene matching)
  • enlarged spleen / MGI
  • abnormal Peyer's patch morphology / MGI
  • decreased thymocyte number / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • weight loss / MGI
  • thymus hypoplasia / MGI
  • conjunctivitis / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal gut-associated lymphoid tissue morphology / MGI
  • no phenotypic analysis / MGI
  • lymph node inflammation / MGI
  • abnormal regulatory T cell morphology / MGI
  • increased regulatory T cell number / MGI
  • decreased regulatory T cell number / MGI
  • increased T cell number / MGI
  • decreased T cell number / MGI
  • decreased double-positive T cell number / MGI
  • cachexia / MGI
  • bradykinesia / MGI
  • abnormal mesenteric lymph node morphology / MGI
  • increased susceptibility to autoimmune disorder / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • increased T cell apoptosis / MGI
  • increased dendritic cell number / MGI
  • abnormal intraepithelial T cell morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • mortality/aging / MGI

Literature references

  • Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.;Wang Ying, Kissenpfennig Adrien, Mingueneau Michael, Richelme Sylvie, Perrin Pierre, Chevrier Stéphane, Genton Céline, Lucas Bruno, DiSanto James P, Acha-Orbea Hans, Malissen Bernard, Malissen Marie, ;2008;Journal of immunology (Baltimore, Md. : 1950);180;1565-75; 18209052
  • Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells.;Lalfer Mélanie, Chappert Pascal, Carpentier Maxime, Urbain Dominique, Davoust Jean M, Gross David-Alexandre, ;2019;Frontiers in immunology;10;521; 30941146

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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