MGI phenotypes (allele matching)
B6.Cg-Tg(Lck-FADD)1Hed/Ieg
| Status | Available to order |
| EMMA ID | EM:01920 |
| Citation information | RRID:IMSR_EM:01920 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Lck-FADD)1Hed/Ieg |
| Alternative name | lck FADD DN |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Lck-FADD)1Hed |
| Gene/Transgene symbol | Tg(Lck-FADD)1Hed |
Information from provider
| Provider | Martin Zoernig |
| Provider affiliation | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt |
| Genetic information | A dominant negative mutant of FADD (coding for aa 80-208 and fused to an amino-terminal AU1 epitope tag) was cloned into the p1017 vector containing the proximal Lck promoter for T cell-specific expression. |
| Phenotypic information | The heterozygous Lck-FADD DN (dominant negative) mice appear normal. Thymocyte and T-cell proliferation is inhibited in vivo and in vitro. |
| Breeding history | Mice were constantly bred to the C57BL/6 background for more than 15 generations. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- A role for FADD in T cell activation and development.;Walsh C M, Wen B G, Chinnaiyan A M, O'Rourke K, Dixit V M, Hedrick S M, ;1998;Immunity;8;439-49; 9586634