MGI phenotypes (allele matching)
B6.Cg-Tg(Lck-FADD)1Hed/Ieg
| Status | Available to order |
| EMMA ID | EM:01920 |
| International strain name | B6.Cg-Tg(Lck-FADD)1Hed/Ieg |
| Alternative name | lck FADD DN |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Lck-FADD)1Hed |
| Gene/Transgene symbol | Tg(Lck-FADD)1Hed |
Information from provider
| Provider | Martin Zoernig |
| Provider affiliation | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt |
| Genetic information | A dominant negative mutant of FADD (coding for aa 80-208 and fused to an amino-terminal AU1 epitope tag) was cloned into the p1017 vector containing the proximal Lck promoter for T cell-specific expression. |
| Phenotypic information | The heterozygous Lck-FADD DN (dominant negative) mice appear normal. Thymocyte and T-cell proliferation is inhibited in vivo and in vitro. |
| Breeding history | Mice were constantly bred to the C57BL/6 background for more than 15 generations. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- A role for FADD in T cell activation and development.;Walsh C M, Wen B G, Chinnaiyan A M, O'Rourke K, Dixit V M, Hedrick S M, ;1998;Immunity;8;439-49; 9586634