IMPC phenotypes (gene matching)
- abnormal retina blood vessel morphology / IMPC
STOCK Gjc3tm1.1Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:01913 |
| International strain name | STOCK Gjc3tm1.1Kwi/Cnrm |
| Alternative name | Cx29 LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gjc3tm1.1Kwi |
| Gene/Transgene symbol | Gjc3 |
Information from provider
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | Instead of exon 2 of Cx29 (Gjc3), a lacZ reporter gene with a nuclear localization signal is inserted in the Cx29 locus, leading to the expression of lacZ under the control of the endogenous Cx29 promoter. One frt site is remaining in the genome 3' of the poly(A)-signal, upon deletion of an frt sites-flanked HPRT-selection cassette. |
| Phenotypic information | None. |
| Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat colored offspring. This brown offspring was backcrossed to C57BL/6NCrl more than 3 times and one time with flp recombinase deleter mice to delete the selection cassette. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Expression pattern and functional characterization of connexin29 in transgenic mice.;Eiberger Jürgen, Kibschull Mark, Strenzke Nicola, Schober Andreas, Büssow Heinrich, Wessig Carsten, Djahed Sina, Reucher Harald, Koch Dirk Alex, Lautermann Jürgen, Moser Tobias, Winterhager Elke, Willecke Klaus, ;2006;Glia;53;601-11; 16435366
- Oxaliplatin-induced neurotoxicity is mediated through gap junction channels and hemichannels and can be prevented by octanol.;Kagiava Alexia, Theophilidis George, Sargiannidou Irene, Kyriacou Kyriacos, Kleopa Kleopas A, ;2015;Neuropharmacology;97;289-305; 26044641