B10.Cg-Plcg2tm1Jni H2d Tg(BCL2)36Wehi Tg(Igh2k3-83)1Nemz/H

Status

Available to order

EMMA IDEM:01892
International strain nameB10.Cg-Plcg2tm1Jni H2d Tg(BCL2)36Wehi Tg(Igh2k3-83)1Nemz/H
Alternative namePlcg2-383/Bcl2-36Tg
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPlcg2tm1Jni, H2d, Tg(BCL2)36Wehi, Tg(Igh2k3-83)1Nemz
Gene/Transgene symbolPlcg2, H2, Tg(BCL2)36Wehi, Tg(Igh23-83)1Nemz

Information from provider

ProviderMartin Turner
Provider affiliationThe Babraham Institute, Babraham, Cambridge, CB2 4PB
Genetic informationThese mice have a null mutation in Plcg2 and display defects in B-lymphocyte function. They also contain a transgene encoding a specific B-cell receptor and a transgene that directs expression of the anti-apoptotic protein Bcl2 to both B- and T-cells.
Phenotypic informationDefects in B-lymphocyte development. High incidence of perinatal lethality. Homozygotes are infertile.
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • PLCG2-associated antibody deficiency and immune dysregulation / Orphanet_300359
    • Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation / Orphanet_324530
IMPC phenotypes (gene matching)
  • increased T cell number / IMPC
  • hyperactivity / IMPC
  • decreased hemoglobin content / IMPC
  • abnormal glucose homeostasis / IMPC
  • thrombocytosis / IMPC
  • decreased hematocrit / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased IgG3 level / IMPC
  • decreased mature B cell number / IMPC
  • decreased circulating free fatty acids level / IMPC
  • increased IgM level / IMPC
  • increased IgG1 level / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased bone mineral density / IMPC
  • increased IgG2b level / IMPC
  • decreased erythrocyte cell number / IMPC
MGI phenotypes (allele matching)
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • abnormal cytokine secretion / MGI
  • increased autoantibody level / MGI
  • decreased susceptibility to parasitic infection / MGI
  • arrested B cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal B cell physiology / MGI
  • decreased susceptibility to induced arthritis / MGI
  • decreased B cell proliferation / MGI
  • abnormal dendritic cell morphology / MGI
  • decreased follicular B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased mature B cell number / MGI
  • increased B cell apoptosis / MGI
  • decreased platelet aggregation / MGI
  • increased transitional stage T2 B cell number / MGI
  • abnormal dendritic cell chemotaxis / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal B cell differentiation / MGI
  • increased susceptibility to viral infection / MGI
  • increased pre-B cell number / MGI
  • decreased osteoclast cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • increased B cell proliferation / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased interferon-gamma secretion / MGI
  • increased trabecular bone thickness / MGI
  • increased trabecular bone volume / MGI
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal cytokine secretion / MGI
  • thyroid inflammation / MGI
  • increased autoantibody level / MGI
  • insulitis / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • periinsulitis / MGI
  • abnormal T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal foot pad morphology / MGI
  • spleen hyperplasia / MGI
  • dermatitis / MGI
  • internal hemorrhage / MGI
  • abnormal humoral immune response / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • abnormal inflammatory response / MGI
  • abnormal lymphatic vessel morphology / MGI
  • premature death / MGI
  • abnormal B cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • chronic inflammation / MGI
  • glomerulonephritis / MGI
  • increased pre-B cell number / MGI
  • decreased susceptibility to induced arthritis / MGI
  • osteoarthritis / MGI
  • decreased osteoclast cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased B cell proliferation / MGI
  • increased B cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal dendritic cell morphology / MGI
  • decreased B-1a cell number / MGI
  • decreased follicular B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • decreased B-2 B cell number / MGI
  • decreased mature B cell number / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased B cell apoptosis / MGI
  • increased trabecular bone thickness / MGI
  • decreased platelet aggregation / MGI
  • increased transitional stage T2 B cell number / MGI
  • abnormal dendritic cell chemotaxis / MGI
  • abnormal NK cell physiology / MGI
  • increased trabecular bone volume / MGI
  • chylous ascites / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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