B10.Cg-Plcg2^tm1Jni H2^d Tg(BCL2)36Wehi Tg(Igh2^k3-83)1Nemz/H

Status	Available to order
EMMA ID	EM:01892
Citation information	RRID:IMSR_EM:01892 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B10.Cg-Plcg2^tm1Jni H2^d Tg(BCL2)36Wehi Tg(Igh2^k3-83)1Nemz/H
Alternative name	Plcg2-383/Bcl2-36Tg
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Plcg2^tm1Jni, H2^d, Tg(BCL2)36Wehi, Tg(Igh2^k3-83)1Nemz
Gene/Transgene symbol	Plcg2, H2, Tg(BCL2)36Wehi, Tg(Igh23-83)1Nemz

Information from provider

Provider	Martin Turner
Provider affiliation	The Babraham Institute, Babraham, Cambridge, CB2 4PB
Genetic information	These mice have a null mutation in Plcg2 and display defects in B-lymphocyte function. They also contain a transgene encoding a specific B-cell receptor and a transgene that directs expression of the anti-apoptotic protein Bcl2 to both B- and T-cells.
Phenotypic information	Defects in B-lymphocyte development. High incidence of perinatal lethality. Homozygotes are infertile.
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

PLCG2-associated antibody deficiency and immune dysregulation / Orphanet_300359
Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation / Orphanet_324530

IMPC phenotypes (gene matching)

increased T cell number / IMPC
hyperactivity / IMPC
decreased hemoglobin content / IMPC
abnormal glucose homeostasis / IMPC
thrombocytosis / IMPC
decreased hematocrit / IMPC
decreased circulating cholesterol level / IMPC
decreased IgG3 level / IMPC
decreased mature B cell number / IMPC
decreased circulating free fatty acids level / IMPC
increased IgM level / IMPC
increased IgG1 level / IMPC
decreased circulating triglyceride level / IMPC
decreased bone mineral density / IMPC
increased IgG2b level / IMPC
decreased erythrocyte cell number / IMPC

MGI phenotypes (allele matching)

decreased hematocrit / MGI
abnormal liver physiology / MGI
abnormal T cell differentiation / MGI
abnormal cytokine secretion / MGI
increased autoantibody level / MGI
decreased susceptibility to parasitic infection / MGI
arrested B cell differentiation / MGI
abnormal dendritic cell physiology / MGI
abnormal B cell physiology / MGI
decreased susceptibility to induced arthritis / MGI
decreased B cell proliferation / MGI
abnormal dendritic cell morphology / MGI
decreased follicular B cell number / MGI
increased pro-B cell number / MGI
decreased mature B cell number / MGI
increased B cell apoptosis / MGI
decreased platelet aggregation / MGI
increased transitional stage T2 B cell number / MGI
abnormal dendritic cell chemotaxis / MGI
abnormal trabecular bone morphology / MGI
abnormal B cell differentiation / MGI
increased susceptibility to viral infection / MGI
increased pre-B cell number / MGI
decreased osteoclast cell number / MGI
impaired natural killer cell mediated cytotoxicity / MGI
increased B cell proliferation / MGI
abnormal osteoclast differentiation / MGI
decreased interferon-gamma secretion / MGI
increased trabecular bone thickness / MGI
increased trabecular bone volume / MGI

MGI phenotypes (gene matching)

decreased hematocrit / MGI
abnormal liver physiology / MGI
abnormal T cell differentiation / MGI
increased susceptibility to bacterial infection / MGI
abnormal immunoglobulin level / MGI
increased IgM level / MGI
abnormal cytokine secretion / MGI
thyroid inflammation / MGI
increased autoantibody level / MGI
insulitis / MGI
increased susceptibility to autoimmune diabetes / MGI
decreased susceptibility to autoimmune diabetes / MGI
decreased susceptibility to parasitic infection / MGI
immune system phenotype / MGI
periinsulitis / MGI
abnormal T cell number / MGI
decreased CD4-positive, alpha beta T cell number / MGI
increased CD8-positive, alpha-beta T cell number / MGI
decreased IgG1 level / MGI
decreased IgG2a level / MGI
increased physiological sensitivity to xenobiotic / MGI
decreased physiological sensitivity to xenobiotic / MGI
increased sensitivity to induced morbidity/mortality / MGI
abnormal trabecular bone morphology / MGI
abnormal foot pad morphology / MGI
spleen hyperplasia / MGI
dermatitis / MGI
internal hemorrhage / MGI
abnormal humoral immune response / MGI
arrested B cell differentiation / MGI
decreased IgM level / MGI
abnormal inflammatory response / MGI
abnormal lymphatic vessel morphology / MGI
premature death / MGI
abnormal B cell differentiation / MGI
abnormal dendritic cell physiology / MGI
increased susceptibility to viral infection / MGI
abnormal B cell physiology / MGI
chronic inflammation / MGI
glomerulonephritis / MGI
increased pre-B cell number / MGI
decreased susceptibility to induced arthritis / MGI
osteoarthritis / MGI
decreased osteoclast cell number / MGI
impaired natural killer cell mediated cytotoxicity / MGI
decreased B cell proliferation / MGI
increased B cell proliferation / MGI
immune system phenotype / MGI
abnormal dendritic cell morphology / MGI
decreased B-1a cell number / MGI
decreased follicular B cell number / MGI
increased pro-B cell number / MGI
decreased transitional stage B cell number / MGI
decreased B-2 B cell number / MGI
decreased mature B cell number / MGI
abnormal osteoclast differentiation / MGI
decreased tumor necrosis factor secretion / MGI
decreased interferon-gamma secretion / MGI
increased B cell apoptosis / MGI
increased trabecular bone thickness / MGI
decreased platelet aggregation / MGI
increased transitional stage T2 B cell number / MGI
abnormal dendritic cell chemotaxis / MGI
abnormal NK cell physiology / MGI
increased trabecular bone volume / MGI
chylous ascites / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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B10.Cg-Plcg2tm1Jni H2d Tg(BCL2)36Wehi Tg(Igh2k3-83)1Nemz/H