STOCK Fasltm1.1Cgm/Ieg
Status | Available to order |
EMMA ID | EM:01885 |
Citation information | RRID:IMSR_EM:01885 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | STOCK Fasltm1.1Cgm/Ieg |
Alternative name | FasL delta intra k.o./k.i. |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Fasltm1.1Cgm |
Gene/Transgene symbol | Fasl |
Information from provider
Provider | Martin Zoernig |
Provider affiliation | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt |
Genetic information | The wild-type Fas ligand (Fasl) allele was replaced with a deletion mutant which lacks the intracellular domain (i.e. aa 2-73). The targeting construct contained a tk-neo fusion cassette flanked by loxP sites for positive selection. This tk-neo cassette has been removed after breeding with CMV-cre recombinase deleter mice. |
Phenotypic information | Homozygous mutants develop a lymphoaccumulation of T-cells in the periphery, similar to Fas ligand-deficient gld/gld mice (of a strain with a Fas ligand spontaneous mutant allele). In addition, mice probably develop autoimmune defects, again similar to gld/gld mice. Therefore, homozygous mice die within 4-6 months of age in the C57BL/6 background. |
Breeding history | Backcrossed to C57BL/6 for 4 generations. |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- decreased granulocyte number / MGI
- enlarged liver / MGI
- abnormal hepatocyte morphology / MGI
- abnormal salivary gland morphology / MGI
- lymphoid hyperplasia / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- enlarged thymus / MGI
- demyelination / MGI
- dermatitis / MGI
- increased metastatic potential / MGI
- abnormal osteoclast physiology / MGI
- anemia / MGI
- focal hepatic necrosis / MGI
- skin edema / MGI
- impaired macrophage phagocytosis / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- autoimmune response / MGI
- brain inflammation / MGI
- eye inflammation / MGI
- liver inflammation / MGI
- interstitial pneumonia / MGI
- neoplasm / MGI
- premature death / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal lymph node morphology / MGI
- abnormal double-negative T cell morphology / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- increased immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- increased IgE level / MGI
- abnormal sperm number / MGI
- glomerulonephritis / MGI
- decreased circulating alanine transaminase level / MGI
- increased urine protein level / MGI
- decreased neuron apoptosis / MGI
- increased autoantibody level / MGI
- abnormal sperm physiology / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- increased spleen weight / MGI
- increased lymphocyte cell number / MGI
- increased T cell number / MGI
- decreased B cell number / MGI
- abnormal cytotoxic T cell physiology / MGI
- decreased cytotoxic T cell cytolysis / MGI
- abnormal T cell proliferation / MGI
- increased B cell proliferation / MGI
- decreased susceptibility to injury / MGI
- increased T cell proliferation / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- vision/eye phenotype / MGI
- abnormal eye electrophysiology / MGI
- increased apoptosis / MGI
- CNS inflammation / MGI
- abnormal retinal nerve fiber layer morphology / MGI
- decreased retinal ganglion cell number / MGI
- increased liver tumor incidence / MGI
- abnormal T cell morphology / MGI
- abnormal retinal ganglion cell morphology / MGI
- retinal ganglion cell degeneration / MGI
- increased plasma cell number / MGI
- increased germinal center B cell number / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- increased circulating tumor necrosis factor level / MGI
- abnormal interleukin level / MGI
- abnormal thymus cell ratio / MGI
- decreased hepatocyte apoptosis / MGI
- increased histiocytic sarcoma incidence / MGI
- abnormal NK cell physiology / MGI
- mortality/aging / MGI
- renal cast / MGI
- glomerular crescent / MGI
- increased lymphoma incidence / MGI
- impaired humoral immune response / MGI
- increased retinal apoptosis / MGI
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