B6;CBACa-Tg(PMP22)C22Clh/H
| Status | Available to order |
| EMMA ID | EM:01883 |
| International strain name | B6;CBACa-Tg(PMP22)C22Clh/H |
| Alternative name | Tg(PMP22)C22Clh |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(PMP22)C22Clh |
| Gene/Transgene symbol | Tg(PMP22)C22Clh |
Information from provider
| Provider | Clare Huxley |
| Provider affiliation | Imperial College, London |
| Genetic information | Yeast artificial chromosome carrying the intact human PMP22 gene. PMP22 is expressed in the peripheral nerves at about 1.7 times the level of the endogenous mouse Pmp22 mRNA. |
| Phenotypic information | Heterozygotes have thin myelin and reduced nerve conduction velocity causing shaky and unsteady gait. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA.;Huxley C, Passage E, Manson A, Putzu G, Figarella-Branger D, Pellissier J F, Fontés M, ;1996;Human molecular genetics;5;563-9; 8733121
- Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice.;Huxley C, Passage E, Robertson A M, Youl B, Huston S, Manson A, Sabéran-Djoniedi D, Figarella-Branger D, Pellissier J F, Thomas P K, Fontés M, ;1998;Human molecular genetics;7;449-58; 9467003