B6;CBACa-Tg(PMP22)C22Clh/H
| Status | Available to order |
| EMMA ID | EM:01883 |
| Citation information | RRID:IMSR_EM:01883 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBACa-Tg(PMP22)C22Clh/H |
| Alternative name | Tg(PMP22)C22Clh |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(PMP22)C22Clh |
| Gene/Transgene symbol | Tg(PMP22)C22Clh |
Information from provider
| Provider | Clare Huxley |
| Provider affiliation | Imperial College, London |
| Genetic information | Yeast artificial chromosome carrying the intact human PMP22 gene. PMP22 is expressed in the peripheral nerves at about 1.7 times the level of the endogenous mouse Pmp22 mRNA. |
| Phenotypic information | Heterozygotes have thin myelin and reduced nerve conduction velocity causing shaky and unsteady gait. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA.;Huxley C, Passage E, Manson A, Putzu G, Figarella-Branger D, Pellissier J F, Fontés M, ;1996;Human molecular genetics;5;563-9; 8733121
- Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice.;Huxley C, Passage E, Robertson A M, Youl B, Huston S, Manson A, Sabéran-Djoniedi D, Figarella-Branger D, Pellissier J F, Thomas P K, Fontés M, ;1998;Human molecular genetics;7;449-58; 9467003