B6.129X1-Sufutm1Rto/Kctt

Status

Available to order

EMMA IDEM:01867
International strain nameB6.129X1-Sufutm1Rto/Kctt
Alternative nameB6.129X1/SvJ-Sufutm1Rto
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolSufutm1Rto
Gene/Transgene symbolSufu

Information from provider

ProviderStephan Teglund
Provider affiliationCell and Molecular Biology, Karolinska Institutet
Genetic informationExon 1 and part of the upstream promoter of the Sufu gene was replaced by a neomycin selection cassette.
Phenotypic informationSufu -/- mutants are embryonic lethal around E9.5 with cephalic and neural tube defects. Heterozygotes develop a skin phenotype with age, characterized by basaloid follicular hamartomas, increased pigmentation, mild alopecia.
References
  • Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.;Svärd Jessica, Heby-Henricson Karin, Persson-Lek Madelen, Rozell Björn, Lauth Matthias, Bergström Asa, Ericson Johan, Toftgård Rune, Teglund Stephan, ;2006;Developmental cell;10;187-97; 16459298

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal limb bud morphology / IMPC
  • pallor / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal placenta size / IMPC
  • embryonic growth retardation / IMPC
  • abnormal liver size / IMPC
  • abnormal embryo size / IMPC
  • abnormal forebrain development / IMPC
  • pale yolk sac / IMPC
  • abnormal stomach morphology / IMPC
  • abnormal hindbrain development / IMPC
  • decreased total body fat amount / IMPC
  • increased startle reflex / IMPC
  • abnormal neural tube closure / IMPC
  • enlarged lymph nodes / IMPC
  • abnormal midbrain development / IMPC
  • cardiovascular system phenotype / IMPC
  • abnormal eye morphology / IMPC
  • pale liver / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
MGI phenotypes (allele matching)
  • alopecia / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal skin appearance / MGI
  • abnormal floor plate morphology / MGI
  • open neural tube / MGI
  • abnormal neural tube morphology / MGI
  • abnormal forebrain development / MGI
  • abnormal midbrain development / MGI
  • abnormal hindbrain development / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • abnormal heart morphology / MGI
  • overriding aortic valve / MGI
  • double outlet right ventricle / MGI
  • alopecia / MGI
  • abnormal craniofacial morphology / MGI
  • microcephaly / MGI
  • polydactyly / MGI
  • exencephaly / MGI
  • abnormal floor plate morphology / MGI
  • open neural tube / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • abnormal somite development / MGI
  • incomplete embryo turning / MGI
  • abnormal dorsal-ventral axis patterning / MGI
  • abnormal left-right axis patterning / MGI
  • edema / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal developmental patterning / MGI
  • abnormal limb morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • micrognathia / MGI
  • no phenotypic analysis / MGI
  • abnormal forebrain development / MGI
  • small lung / MGI
  • abnormal neural tube closure / MGI
  • abnormal midbrain development / MGI
  • embryonic growth retardation / MGI
  • abnormal primitive node morphology / MGI
  • abnormal coronary artery morphology / MGI
  • failure of initiation of embryo turning / MGI
  • abnormal direction of heart looping / MGI
  • abnormal myocardium layer morphology / MGI
  • abnormal hindbrain development / MGI
  • abnormal skin appearance / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • descending aorta dilation / MGI
  • coronary fistula / MGI
  • brain aneurysm / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • abnormal head shape / MGI

Literature references

  • Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.;Svärd Jessica, Heby-Henricson Karin, Persson-Lek Madelen, Rozell Björn, Lauth Matthias, Bergström Asa, Ericson Johan, Toftgård Rune, Teglund Stephan, ;2006;Developmental cell;10;187-97; 16459298

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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